Browsing by Author "KELLY, DANIEL"
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A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.
KELLY, DANIEL; BUCKLEY, CONOR (2014)Despite an increased interest in the use of hydrogel encapsulation and cellular self-assembly (often termed "self-aggregating" or "scaffold-free" approaches) for tissue-engineering applications, to the best of our knowledge, ... -
The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
KELLY, DANIEL (2013)The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA (2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.
Prendergast, Patrick; LENNON, ALEXANDER; KELLY, DANIEL; BOYLE, COLIN; EARLY, MICHAEL; LALLY, CAITRIONA (2010)The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response ... -
Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis.
KELLY, DANIEL; VINARDELL, TATIANA; BUCKLEY, CONOR (2015) -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
BUCKLEY, CONOR; KELLY, DANIEL (2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study.
O'REILLY, PETER; KELLY, DANIEL (2011)BACKGROUND AND PURPOSE: The two most common complications of femoral impaction bone grafting are femoral fracture and massive implant subsidence. We investigated fracture forces and implant subsidence rates in embalmed ... -
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model.
KELLY, DANIEL (2009)Tissue-engineered bone shows promise in meeting the huge demand for bone grafts caused by up to 4 million bone replacement procedures per year, worldwide. State-of-the-art bone tissue engineering strategies use flow perfusion ... -
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
VINARDELL, TATIANA; KELLY, DANIEL; CAMPBELL, VERONICA ANN; BUCKLEY, CONOR TIMOTHY (2008)The objective of this study was to investigate the influence of dynamic compressive loading on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-?3. Isolated porcine MSCs were suspended in 2% agarose ... -
Ecology and mode-of-life explain lifespan variation in birds and mammals.
KELLY, DANIEL (2014)Maximum lifespan in birds and mammals varies strongly with body mass such that large species tend to live longer than smaller species. However, many species live far longer than expected given their body mass. This may ... -
Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis
KELLY, DANIEL; Prendergast, Patrick John (Springer, 2004)The structure and functionality of tissue-engineered cartilage is determined by the tissue culture conditions and mechanical conditioning during growth. The quality of tissue-engineered cartilage can be evaluated using ... -
The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells
KELLY, DANIEL; BUCKLEY, CONOR (2011)Mechanical signals can play a key role in regulating the chondrogenic differentiation of Mesenchymal Stem Cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure ... -
The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses
KELLY, DANIEL; Prendergast, Patrick John (Wolters Kluwer, 2003)Hypothesis: We hypothesize that the differences in the bioacoustic performance of ossicular replacement prosthesis designs, and insertion positions, can be quantified using finite element analysis. Background: Many ... -
Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels.
VINARDELL, TATIANA; KELLY, DANIEL (2015)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown to generate bone in vivo by executing an endochondral programme. This may hinder the use of MSCs for articular cartilage regeneration, ... -
Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions
KELLY, DANIEL; NELSON SATHY, BINULAL; DALY, ANDREW (2018) -
Engineering osteochondral constructs through spatial regulation of endochondral ossification.
KELLY, DANIEL; BUCKLEY, CONOR (2013)Chondrogenically primed bone marrow derived mesenchymal stem cells (MSCs) have been shown to become hypertrophic and undergo endochondral ossification when implanted in vivo. Modulating this endochondral phenotype may ...