Browsing by Author "KELLEHER, DERMOT P"
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Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity
DAVIES, ANTHONY; VOLKOV, YURI; WILLIAMS, YVONNE; PRINA MELLO, ADRIELE; KELLEHER, DERMOT P (2011)Background: Nanomaterials such as SiO2 nanoparticles (SiO2NP) are finding increasing applications in the biomedical and biotechnological fields such as disease diagnostics, imaging, drug delivery, food, cosmetics and ... -
Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells
KELLEHER, DERMOT P; SABRA, KAMAL; WINDLE, HENRY (Nature, 2005)Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives (honeybee resin), has anti-inflammatory, anti-carcinogenic and anti-bacterial properties. This study was designed to investigate the ... -
CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes
VOLKOV, YURI; KELLEHER, DERMOT P (2005) -
Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78
KELLEHER, DERMOT P (The American Society for Biochemistry and Molecular Biology, 1995)Tumor necrosis factor (TNF) is a pleiotropic cytokine which has both cytotoxic and proliferative effects. HuT 78, a T-cell line derived from a Sezary lymphoma, is resistant to the cytotoxic effects of TNF, suggesting that ... -
Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells
KELLEHER, DERMOT P (BMJ, 1997)BACKGROUND: Elements of the mucosal immune system may play an important part in regulating epithelial barrier function in the intestinal tract. Intraepithelial lymphocytes (IELs) represent a subtype of immunocyte which is ... -
Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme
KELLEHER, DERMOT P; TIPTON, KEITH; WINDLE, HENRY (John Wiley, 2005)Cinnamyl alcohol dehydrogenases (CAD; 1.1.1.195) catalyse the reversible conversion of p-hydroxycinnamaldehydes to their corresponding alcohols, leading to the biosynthesis of lignin in plants. Outside of plants their role ... -
Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?
KELLEHER, DERMOT P (American Academy of Paediatrics, 2007)We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment. ... -
Chronic granulomatous disease presenting as an oculomucocutaneous syndrome mimicking Behcet's syndrome
FEIGHERY, CONLETH FRANCIS; GRIFFIN, MAIREAD; KELLEHER, DERMOT P; MCCANN, SHAUN (BMJ, 1986)A female patient who presented for the first time at the age of 19 with oculomucocutaneous syndrome was found to have an absolute deficiency of neutrophil peroxide production. Neutrophil peroxide production as measured by ... -
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
KELLEHER, DERMOT P; MCMANUS, ROSS (Nature, 2001)The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares ... -
Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
KELLEHER, DERMOT P; MILLS, KINGSTON; ROCHE, HELEN (The American Association of Immunologists, 2005)Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. However, the influence of PUFA on dendritic cells (DC), key cells of the innate immune ... -
Cutting edge: protein kinase C beta expression is critical for export of Il-2 from T cells
VOLKOV, YURI; KELLEHER, DERMOT P; LONG, AIDEEN (2001) -
Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease
KELLEHER, DERMOT P (BMJ, 1989)T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced ... -
Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells
DUGGAN, SHANE; KELLEHER, DERMOT P; LONG, AIDEEN (BioMed Central, 2009)Background The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role ... -
Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum.
KELLEHER, DERMOT P; MURPHY, ANNE; SHEILS, ORLA (Hindawi, 2005)Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ... -
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY (2011)The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first ... -
Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes.
KELLEHER, DERMOT P; O'FARRELLY, CLIONA (Taylor and Francis, 1995)Bromodeoxyuridine incorporation is a useful method for studying the pattern of DNA synthesis in proliferating cells. The distribution pattern of incorporated BrdU in villus enterocytes of duodenal explants was analysed ... -
Engagement of CD44 Modulates cyclooxygenase induction, VEGF generation, and cell proliferation in human vascular endothelial cells
KELLEHER, DERMOT P; MURPHY, JOSEPH (The Federation of American Socieites for Experimental Biology, 2005)CD44 is a receptor for hyaluronic acid and is found on the surface of hematopoetic cells and in mesenchymal tissue. It is also expressed on endothelial cells (EC). Cyclooxygenase (COX) is the rate-limiting enzyme in the ... -
The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen
KELLEHER, DERMOT P; WEIR, DONALD (Nature, 2002)Epidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen. Systemic diseases are often associated with epidermolysis bullosa acquisita, ... -
Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis
KELLEHER, DERMOT P; WEIR, DONALD (John Wiley, 2002)BACKGROUND: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). AIM: To evaluate the effects of 9 months of therapy with mesalazine ... -
Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation
KELLEHER, DERMOT P (BMJ, 1996)BACKGROUND--Studies have suggested that expression of the adhesion molecule CD44 may be of prognostic importance in gastric cancer. In addition, there is strong evidence that Helicobacter pylori has a role in gastric cancer. ...