Browsing by Author "KELLEHER, DERMOT P"
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Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
KELLEHER, DERMOT P (American Society for Clinical Investigation, 2009)There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single ... -
Low pH results in co-ordinate regulation of gene expression in oesophageal cells
KELLEHER, DERMOT P; REYNOLDS, JOHN; DUGGAN, SHANE (2006) -
Microalbuminuria correlates with intestinal histopathological grading in patients with inflammatory bowel disease
KELLEHER, DERMOT P (BMJ, 1996)It has previously been shown that microalbuminuria is a useful disease activity marker for inflammatory bowel disease (IBD). Microalbuminuria correlates strongly with the markers of clinical and laboratory disease activity ... -
Microalbuminuria in inflammatory bowel disease
KELLEHER, DERMOT P (BMJ, 1994)Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined ... -
Nanodrug applications in photodynamic therapy.
EHRHARDT, CARSTEN; SENGE, MATHIAS; KELLEHER, DERMOT P; REYNOLDS, JOHN (2011) -
Neurofilament expression in human T lymphocytes
FEIGHERY, CONLETH FRANCIS; KELLEHER, DERMOT P; LONG, AIDEEN; MURPHY, ANNE (British Society for Immunology, 1993)The expression of intermediate filaments in normal cells is mainly determined by their embryonal developmental origin. Flow cytometry using monoclonal antibody RT97 demonstrated that neurofilament was detectable in the ... -
NF-kappaB Activation in Esophageal Adenocarcinoma: Relationship to Barrett's Metaplasia, Survival, and Response to Neoadjuvant Chemoradiotherapy
KELLEHER, DERMOT P; WINDLE, HENRY (Lippincott Williams & Wilkins, 2004)OBJECTIVE: To examine the expression of the transcription factor nuclear factor kappa B (NF-kappaB) in Barrett's epithelium and adenocarcinoma and the impact of NF-kappaB expression on tumor stage and response to neoadjuvant ... -
Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study
KELLEHER, DERMOT P; O'MORAIN, COLM ANTOINE; WEIR, DONALD (BMJ, 2001)BACKGROUND AND AIMS: The benefit of 5-aminosalicylic acid therapy for maintenance of remission in Crohn's disease is controversial. The primary aim of this study was to evaluate the prophylactic properties of olsalazine ... -
Perioperative serum inflammatory response and the development of atrial fibrilation after coronary artery bypass surgery
BENNETT, KATHLEEN; CREAN, PETER; KELLEHER, DERMOT P (BMJ, 2005)Atrial fibrillation (AF) remains the most common cardiac arrhythmia and is associated with an increase in both morbidity and mortality. Some data in both the surgical and non-surgical settings suggest that inflammation has ... -
Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytes
KELLEHER, DERMOT P (Blackwell, 1995)Differences in levels of specific enzymes utilized in intracellular signalling could be a factor in the distinct signalling properties observed in memory and naive T cells. We have studied the expression of both classical ... -
Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line
KELLEHER, DERMOT P; LONG, AIDEEN (British Society for Immunology, 1993)Using the T-cell lymphoma line HuT 78, and a clone derived from HuT 78, designated K-4, the role of protein kinase C (PKC) isozymes in the expression of a variety of T-cell surface antigens was investigated. HuT 78 expresses ... -
Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites
LONG, AIDEEN; FREELEY, MICHAEL GERARD; KELLEHER, DERMOT P (Elsevier, 2011)Protein Kinase C (PKC) is a family of serine/threonine kinases whose function is influenced by phosphorylation. In particular, three conserved phosphorylation sites known as the activation-loop, the turn-motif and the ... -
The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells
KELLEHER, DERMOT P; VOLKOV, YURI (2006) -
A Semi-Automatic Indexing System for Cell Images
AHMAD, KHURSHID; Zheng, Choaxin; KELLEHER, DERMOT P (IEEE, 2008)A method is described that can be used for annotating and indexing an arbitrary set of images with texts collateral to the images. The collateral texts comprise digitised texts, e.g. journal papers and newspapers in which ... -
Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study.
CROWLEY, VIVION; KELLEHER, DERMOT P; MCMANUS, ROSS; RYAN, THOMAS (BioMed Central, 2006)INTRODUCTION: Asymmetrical dimethyl arginine (ADMA) is an endogenous non-selective inhibitor of nitric oxide synthase that may influence the severity of organ failure and the occurrence of shock secondary to an infectious ... -
Sequence and phylogenetic analysis of the gene for surface layer protein, slpA, from 14 PCR ribotypes of Clostridium difficile
KELLEHER, DERMOT P (Society for General Microbiology, 2006)Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA ... -
Soluble extracts from Helicobacter pylori induce dome formation in polarized intestinal epithelial monolayers in a laminin-dependent manner
KELLEHER, DERMOT P; WINDLE, HENRY (American Society for Microbiology, 2003)Helicobacter pylori colonizes the stomach at the interface between the mucus layer and the apical pole of gastric epithelial cells. A number of secreted and shed products from the bacteria, such as proteins and lipopolysaccharide, ... -
St Johns wort increases expression of P-glycoprotein: implications for drug interactions
HENNESSY, MARTINA JOAN; KELLEHER, DERMOT P; SPIERS, JAMES PAUL (Blackwell, 2002)AIMS: St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in ... -
The thioredoxin system of Helicobacter pylori
KELLEHER, DERMOT P (The American Society for Biochemistry and Molecular Biology, 2000)This paper describes the purification of thioredoxin reductase (TR) and the characterization, purification, and cloning of thioredoxin (Trx) from Helicobacter pylori. Purification, amino acid sequence analysis, and molecular ... -
Tyrosine phosphorylation in the human duodenum.
KELLEHER, DERMOT P; SHEILS, ORLA (BMJ, 1995)Many growth factor receptors including the epidermal growth factor receptor function through tyrosine kinase activity. The aim of this study was to examine the constitutive level of tyrosine phosphorylation in the normal ...