Browsing by Author "GILL, MICHAEL"
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Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD
GILL, MICHAEL (2010)Some children with ADHD also have social and communication difficulties similar to those seen in children with autistic spectrum disorders and this may be due to shared genetic liability. As the oxytocin receptor (OXTR) ... -
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.
GILL, MICHAEL; HAWI, ZIARIH (2002)Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.1,2 Two recently published studies have implicated variation at a ... -
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
CORVIN, AIDEN; HERON, ELIZABETH; GILL, MICHAEL; DONOHOE, GARY; ANNEY, RICHARD; GALLAGHER, LOUISE; MORRIS, DEREK; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Exploration of empirical Bayes hierarchical modeling for the analysis of genome-wide association study data.
GILL, MICHAEL; HERON, ELIZABETH ANN; GALLAGHER, LOUISE (2011)In the analysis of genome-wide association (GWA) data, the aim is to detect statistical associations between single nucleotide polymorphisms (SNPs) and the disease or trait of interest. These SNPs, or the particular regions ... -
Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder.
GILL, MICHAEL; HARKIN, ANDREW; MORRIS, DEREK; O'KEANE, VERONICA (2014) -
Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.
GILL, MICHAEL (2015)BACKGROUND: Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on ... -
Familiality of Co-existing ADHD and Tic Disorders: Evidence from a Large Sibling Study.
GILL, MICHAEL (2016)Background: The association of attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination ... -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; QUINN, EMMA (2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ... -
fMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD
JOHNSON, KATHERINE; BARRY, EDWINA; ROBERTSON, IAN; GARAVAN, HUGH; HAWI, ZIARIH; MULLIGAN, AISLING; GILL, MICHAEL (2011)The DAT1 gene codes for the dopamine transporter, which clears dopamine from the synaptic cleft, and a variant of this gene has previously been associated with compromised response inhibition in both healthy and clinical ... -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
GILL, MICHAEL; MORRIS, DEREK; KENNY, ELAINE; CORVIN, AIDEN (2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.
ANNEY, RICHARD; GILL, MICHAEL (2011)BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We ... -
Functionality of promoter microsatellites of arginine vasopressin receptor 1A (AVPR1A): implications for Autism.
ANNEY, RICHARD JAMES LEON; GILL, MICHAEL; GALLAGHER, LOUISE (BIOMED CENTRAL, 2011)Background: Arginine vasopressin (AVP) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. The arginine vasopressin receptor 1A gene (AVPR1A) ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
GILL, MICHAEL; DONOHOE, GARY; CORVIN, AIDEN; MORRIS, DEREK; FRODL, THOMAS (2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
GILL, MICHAEL (The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
GILL, MICHAEL; GALLAGHER, LOUISE; ANNEY, RICHARD; KENNY, ELAINE (2011)Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ... -
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
GILL, MICHAEL (2014)BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify ... -
Genetic Classification of Populations using Supervised Learning.
GILL, MICHAEL; MORRIS, DEREK; HERON, ELIZABETH; CORVIN, AIDEN; PINTO, CARLOS (2011)There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure. Examples include populations which are geographically ... -
Genetic effects influencing risk for major depressive disorder in China and Europe
HARDIMAN, ORLA; GILL, MICHAEL; Bigdeli, T.B.; Ripke, S.; Peterson, R.E.; Trzaskowski, M.; Bacanu, S.-A.; Abdellaoui, A.; Andlauer, T.F.M.; Beekman, A.T.F.; Berger, K.; Blackwood, D.H.R.; Bloomsma, D.I.; Breen, G.; Buttenschøn, H.N.; Byrne, E.M.; Cichon, S.; Clarke, T.-K.; Couvy-Duchesne, B.; Craddock, N.; de Geus, E.J.C.; Degenhardt, F.; Dunn, E.C.; Edwards, A.C.; Fanous, A.H.; Forstner, A.J.; Frank, J.; Gill, M.; Gordon, S.D.; Grabe, H.J.; Hamilton, S.P.; Hayward, C.; Heath, A.C.; Henders, A.K.; Herms, S.; Hickie, I.B.; Hoffman, P.; Homuth, G.; Hottenga, J.-J.; Ising, M.; Jansen, R.; CONVERGE consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2017)Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex ... -
Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis.
GILL, MICHAEL (2014)Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol ...