Browsing by Author "CORVIN, AIDEN PETER"
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Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL (2009)We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that ... -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
CORVIN, AIDEN PETER (2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
CORVIN, AIDEN PETER; GILL, MICHAEL (The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ... -
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER (2012)Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer?s disease and vascular risk factors. Our genome-wide association study of dementia- free persons (n=9,232) identified 46 ... -
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
CORVIN, AIDEN PETER (2011)Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We carried out a GWA study on glycaemic response to metformin in 1024 Scottish patients with type 2 diabetes. Replication was in two cohorts ... -
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
CORVIN, AIDEN PETER (2012)Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility ... -
Development of Strategies for SNP Detection in RNA-Seq Data: Application to Lymphoblastoid Cell Lines and Evaluation Using 1000 Genomes Data.
MORRIS, DEREK; ANNEY, RICHARD JAMES LEON; CORVIN, AIDEN PETER; GILL, MICHAEL (2013)Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality ... -
Dissection of the genetics of Parkinson's disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21
CORVIN, AIDEN PETER (Oxford University Press, 2010)We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 ... -
Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?
GARAVAN, HUGH PATRICK; ROBERTSON, IAN; CORVIN, AIDEN PETER; MORRIS, DEREK WILLIAMS; DONOHOE, GARY (JAMES) (Cambridge University Press, 2006)Background: Despite its inhibitory control requirements, antisaccade deficits have been consistently associated with working memory impairments in schizophrenia. We investigated whether variance in antisaccade per formance ... -
The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function.
MORRIS, DEREK; MC GRATH, JANE; ROBERTSON, IAN H; NEWELL, FIONA; O'DOHERTY, JOHN PHILIP; GILL, MICHAEL; TROPEA, DANIELA; DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN (2012)A single nucleotide polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia in recent genome-wide association studies. To date, there has been little ... -
Failure to validate association between 12p13 variants and ischaemic stroke
CORVIN, AIDEN PETER (2010)We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 ... -
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
CORVIN, AIDEN PETER (2011)Multiple sclerosis (OMIM 126200) is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance ... -
Genome-wide association studies: a primer.
CORVIN, AIDEN PETER (Cambridge University Press, 2010)There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex ... -
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
CORVIN, AIDEN PETER (2012)Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 ... -
Genome-wide association study identifies five new schizophrenia loci.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL; DONOHOE, GARY (JAMES) (2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
CORVIN, AIDEN PETER (2009)Ulcerative colitis (UC) is a common form of inflammatory bowel disease with a complex aetiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome- wide association scan for UC in 2361 cases ... -
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
CORVIN, AIDEN PETER (Nature Publishing Group, 2009-11-15)Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 ... -
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN PETER; MORRIS, DEREK (Nature, 2010)We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
CORVIN, AIDEN PETER; GILL, MICHAEL; MORRIS, DEREK (2009)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...