Browsing by Author "MORRIS, DEREK"
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Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways
MORRIS, DEREK; KELLY, DANIEL; Prendergast, Patrick; ROLFE, REBECCA (2014)Background Mechanical stimulation is necessary for regulating correct formation of the skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal system impacts expression levels of genes ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
CORVIN, AIDEN PETER; GILL, MICHAEL; MORRIS, DEREK (2009)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ... -
Implication of a Rare Deletion at Distal 16p11.2 in Schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2013) -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN; O'DONOGHUE, THERESE; GILL, MICHAEL; QUINN, EMMA (2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals.
GILL, MICHAEL; DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN (2014) -
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK (2014)It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ... -
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.
KENNY, ELAINE; MORRIS, DEREK; O DUSHLAINE, COLM; CORVIN, AIDEN; DONOHOE, GARY; HERON, ELIZABETH; GILL, MICHAEL (2011)Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants each of small effect. Identifying if risk variants map to specific molecular ... -
Multiplex Target Enrichment Using DNA Indexing for Ultra-High Throughput SNP Detection.
KENNY, ELAINE; GILKS, WILLIM PETER; CORMICAN, PAUL; MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL; PINTO, CARLOS (2011)Screening large numbers of target regions in multiple DNA samples for sequence variation is an important application of next-generation sequencing but an efficient method to enrich the samples in parallel has yet to be ... -
Mutation of Semaphorin-6A Disrupts Limbic and Cortical Connectivity and Models Neurodevelopmental Psychopathology
GILL, MICHAEL; MORRIS, DEREK; CORVIN, AIDEN; MITCHELL, KEVIN (2011)Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation and dysconnectivity across the brain and can be caused by mutations in genes that control neurodevelopmental processes. ... -
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
HERON, ELIZABETH; DONOHOE, GARY; MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2014)Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ... -
Non-random error in genotype calling procedures: Implications for family-based and case-control genome-wide association studies
MORRIS, DEREK; GILL, MICHAEL (2008) -
A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; FAHEY, CIARA (Wiley Open Access, 2012)Background: The nitric oxide synthasase‐1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
GILL, MICHAEL; MORRIS, DEREK; CORVIN, AIDEN; DONOHOE, GARY; KELLEHER, DERMOT (2014) -
The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis
HARGREAVES, APRIL; GILL, MICHAEL; MORRIS, DEREK; ANNEY, RICHARD; CORVIN, AIDEN; DONOHOE, GARY (2013) -
Population structure and genome-wide patters of variation in Ireland and Britain.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK (2010) -
The Psychosis Susceptibility gene ZNF804A: associations, functions and phenotypes
CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK (2010)As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and ...