Browsing by Author "MILLS, KINGSTON"
Now showing items 21-40 of 89
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Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus
(SGM, 1991)Immunization of BALB/c mice with a single dose of the Sabin type 1, type 2 or type 3 poliovirus vaccine strains stimulated cross-reactive T helper cell responses detected by both in vitro proliferation and interleukin ... -
Cellular immunity in pertussis
(The Pathological Society of Great Britain and Ireland, 1993) -
Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation
(The American Association of Immunologists, 2003)It has previously been reported that cholera toxin (CT) is a potent mucosal adjuvant that enhances Th2 or mixed Th1/Th2 type responses to coadministered foreign Ag. Here we demonstrate that CT also promotes the generation ... -
Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
(The American Association of Immunologists, 2005)Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. However, the influence of PUFA on dendritic cells (DC), key cells of the innate immune ... -
A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis
(The Rockefeller University Press, 2006)It was recently demonstrated that interleukin (IL)-23?driven IL-17?producing (ThIL-17) T cells mediate inflammatory pathology in certain autoimmune diseases. We show that the induction of antigen-specific ThIL-17 cells, ... -
Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children
(British Society for Immunology, 1998)Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection ... -
Diversity of the class II (I-Ak/I-Ek) restricted T-cell repertoire for influenza haemagglutinin and antigenic drift: six non-overlapping epitopes on the HA1 sub-unit are defined by synthetic peptides
(The Rockefeller University Press, 1989)H-2k-restricted T cell clones derived from CBA mice infected with X31 (H3N2) influenza virus, were shown to recognize distinct, nonoverlapping sequences within the HA1 subunit of the viral hemagglutinin (HA) using synthetic ... -
Effective immunization against Bordetella pertussis respiratory infection of mice is dependant on the induction of cell mediated immunity
(American Society for Microbiology, 1993)A murine respiratory challenge model was used to examine the induction of cellular and humoral immune responses and their role in protection against Bordetella pertussis following immunization or previous infection. Spleen ... -
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent
(2004)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis
(The American Society for Microbiology, 1999)Fasciolosis, like other helminth infections, is associated with the induction of T-cell responses polarized to the Th2 subtype. Respiratory infection with Bordetella pertussis or immunization with a pertussis whole-cell ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
(2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases
(2011)Neuroinflammatory changes are characteristic of many, if not all, neurodegenerative diseases but the extent to which the immune system is involved in the pathogenesis of these diseases is unclear. The findings of several ... -
Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.
(2013)Vaccines that promote protective adaptive immune responses have been successfully developed against a range of infectious diseases, and these are normally administered prior to exposure with the relevant virus or bacteria. ... -
Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin a in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan
(American Society for Microbiology, 2005)Thirty-six healthy volunteers received either a single intramuscular injection of Neisseria meningitidis serogroup C polysaccharide (MCP)-CRM197 conjugate vaccine in alum or two nasal insufflations 28 days apart of the ... -
Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
(2010)Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis, where disease is mediated by autoantigen-specific T cells. Although there is evidence linking CD4+ T cells that secrete IL-17, termed ... -
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
(2010)Inflammasome-mediated IL-1? production is central to the innate immune defects that give rise to certain autoinflammatory diseases and may also be associated with the generation of IL-17?producing CD4+ T (Th17) cells that ... -
Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease.
(2009)IL-17 producing CD4+ T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including IL-23 and IL-1?, produced by innate immune cells through ...
