Browsing by Author "FOSTER, TIMOTHY"
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Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus
FOSTER, TIMOTHY (1983)A DNA sequence encoding Staphylococcus aureus alpha-hemolysin, which had been previously cloned and mapped in Escherichia coli K-12, was introduced into Bacillus subtilis BD170 and several strains of S. aureus by using ... -
Fibrinogen activates the capture of human plasminogen by staphylococcal fibronectin-binding proteins
FOSTER, TIMOTHY (2017)Invasive bacterial pathogens can capture host plasminogen (Plg) and al- low it to form plasmin. This process is of medical importance as surface-bound plas- min promotes bacterial spread by cleaving tissue components and ... -
Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus
FOSTER, TIMOTHY (2007)The fibronectin binding protein, FnBPA, is a multifunctional microbial surface component recognizing adhesive matrix molecule (MSCRAMM) that promotes bacterial adherence to immobilized fibrinogen and elastin via the ... -
Fibrinogen is a ligand for the S. aureus MSCRAMM Bbp (Bone sialoprotein-binding protein).
FOSTER, TIMOTHY (2011)MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are bacterial surface proteins mediating adherence of the microbes to components of the extracellular matrix of the host. On Staphylococci the ... -
Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2015)In this study, we investigated the cell wall-anchored fibronectin-binding proteins SpsD and SpsL from the canine commensal and pathogen Staphylococcus pseudintermedius for their role in promoting bacterial invasion of ... -
Fibronectin-binding protein B variation in Staphylococcus aureus
FOSTER, TIMOTHY; BURKE, FIONA; MCCORMACK, NIAMH (2010)Background: Fibronectin binding proteins A and B (FnBPA and FnBPB) mediate adhesion of S.aureus to fibrinogen, elastin and fibronectin. We previously identified seven different isotopes of FnBPA based on divergence in the ... -
Fibronectin‐binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcγRIIa receptor
FOSTER, TIMOTHY (2006)Staphylococcus aureus is a leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is an important step in the pathogenesis of IE. Here, we ... -
Fluid Gels: a New Feedstock for High Viscosity Jetting
FOSTER, TIMOTHY (2018)Suspensions of gel particles which are pourable or spoonable at room temperature can be created by shearing a gelling biopolymer through its gelation (thermal or ion mediated) rather than allowing quiescent cooling – thus ... -
The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin
FOSTER, TIMOTHY (1993)The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the gamma 1 and gamma 2 components, respectively. ... -
Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor
FOSTER, TIMOTHY (1992)Staphylococcus aureus Newman cells carry a surface receptor for fibrinogen called clumping factor. The bacteria also express coagulase, an extracellular protein that binds to prothrombin to form a complex with thrombinlike ... -
Genetic manipulation of Staphylococci-breaking through the barrier
FOSTER, TIMOTHY (2012) -
Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2011) -
Identification of the merR gene of R100 by using mer-lac gene and operon fusions
FOSTER, TIMOTHY (1985)Transcriptional (operon) and translational (gene) fusions between the R100 merR gene and lacZ were constructed in vitro in a pBR322 plasmid carrying the mer genes derived from plasmid R100. The translational fusions were ... -
Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen.
FOSTER, TIMOTHY; MIAJLOVIC, HELEN (2008) -
The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2012)The Sbi protein of Staphylococcus aureus comprises two IgG binding domains similar to those of protein A and a region that triggers the activation of complement C3. Sbi is expressed on the cell surface but its C-terminal ...