Browsing by Author "CORVIN, AIDEN"
Now showing items 21-40 of 73
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Evidence that duplications of 22q11.2 protect against schizophrenia.
(2014)A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 ... -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
(2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ... -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
(2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
(2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Genes predict village of origin in rural Europe.
(2010)The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate ... -
Genetic Classification of Populations using Supervised Learning.
(2011)There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure. Examples include populations which are geographically ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
(2015)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
(2015)Atopic dermatitis and psoriasis are the two most common immune-mediated inflammatory disorders affecting the skin. Genome-wide studies demonstrate a high degree of genetic overlap, but these diseases have mutually exclusive ... -
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
(2017)The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ... -
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
(2016)The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still ... -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
(2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ...
