Browsing by Subject "Ph.D. Trinity College Dublin."
Now showing items 21-40 of 242
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An investigation of implicit and explicit 'liking' and 'wanting' processes in nicotine addiction
(Trinity College (Dublin, Ireland). School of Psychology, 2012)Research indicates that drug related stimuli acquire the ability to elicit attention and approach biases in heavily dependent drug users. Incentive motivation models of addiction propose that excessive attribution o f ... -
An investigation of structure-function relations in articular cartilage during skeletal maturation
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The over-riding objective of this thesis was to build upon our current understanding of the evolving nature of articular cartilage mechanics by elucidating how changes to structure and composition of the tissue during ... -
Analysis of the gene regulatory network underlying reproductive floral organ development through gene perturbation experiments
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Homeosis or homeotic transformation refers to the formation of one body structure or organ in place of another. For more than two decades, the floral homeotic genes have been at the center of intense studies that showed ... -
And God seith...': representations of divine speech and personal relationship to God in Middle English literature
(Trinity College (Dublin, Ireland). School of English, 2009)This thesis aims to analyse the diegetic representation of divine discourse, in particular, the reported speech of God in Middle English literature. It focuses on the narratorial stance of key texts towards such representations ... -
Antibodies prevent the acute inhibition of long term potentiation by amyloid beta in the rat hippocampus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)The present study investigated the mechanisms underlying the inhibition of long-term potentiation (LTP) of excitatory synaptic transmission by amyloid beta (Aβ) in the anaesthetized rat hippocampus. The role of soluble Aβ ... -
Applying a practice lens to strategic information systems planning : a senior management perspective
(Trinity College (Dublin, Ireland). Trinity Business School, 2015)This study examines the practice of strategic information systems (SISP) planning by senior managers. The research topic was initially formed by the researcher's keen interest in the strategy and information systems (IS) ... -
Atomistic models and time-dependent simulations of spin dynamics in isolated and current-carrying systems
(Trinity College (Dublin, Ireland). School of Physics, 2012)Understanding and ultimately controlling the dynamics of electrons and their spins is an important aspect of spin-based electronics. Recent experimental advances open up new possibilities for probing spin dynamics with ... -
Authoring our culture : using narrative to explore the student-learner's understanding of self within the educative relationship
(Trinity College (Dublin, Ireland). School of Education, 2012)This study was interested in looking into the life and experience of ordinary teenaged secondary students and set out to discover their themes of self and the place of these themes within the educative relationship. This ... -
Autobiographical progression : Christa Wolf's Nachdenken über Christa T., Kindheitsmuster and Ein Tag im Jahr
(Trinity College (Dublin, Ireland). Department of Germanic Studies, 2009)Christa Wolf's Nachdenken über Christa T., Kindheitsmuster and Ein Tag im Jahr constitute a significant contribution to the field of women's autobiographical writing in their in-depth questioning of autobiographical ... -
Bayesian methods for evidence synthesis and decision making in Health Technology Assessments
(Trinity College (Dublin, Ireland). School of Computer Science & Statistics, 2013)In this thesis statistical methodologies to improve reimbursement decisions in healthcare are developed. The allocation of healthcare resources is a very topical issue in the current economic climate. Given a limited ... -
Characterisation of the second binding protein of immunoglobulin (SBi) in Straphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The second binding protein for immunoglobulin (Sbi) of Staphylococcus aureus comprises two IgG binding domains (D1 and D2) that share 30% sequence homology with the IgG binding domains of protein A (Spa) and two domains ... -
Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles, are strong activators of antigen-specific humoral immunity. These particulates enhance NLRP3 inflammasome activation, but they are ... -
Collective organisation and external regulation of professional rugby league in the United Kingdom
(Trinity College (Dublin, Ireland). School of Law, 2010)This thesis examines the external regulation of professional rugby league in the United Kingdom. It considers specifically the employment of players in the Super League competition by British clubs. In the course of this ... -
Compiler techniques to improve indirect branch prediction
(Trinity College (Dublin, Ireland). School of Computer Science & Statistics, 2012)Computers employ a class of branches called indirect branches to realize various programming language features. Multiway branching (switch statements), virtual function dispatch and function calls are all realized through ... -
Composite scaffold development and bioreactor culture for bone tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Bone tissue engineering involves seeding bone cells onto a scaffold, culturing this construct so that mineralisation occurs (by using signalling mechanisms such as growth factors or bioreactors) and then implanting it into ... -
Conductance probe microscopy investigation on the local electronic properties of single walled carbon nanotube systems
(Trinity College (Dublin, Ireland). School of Chemistry, 2010)In order to build electronic devices and circuits comprised of nanoscale materials as the active element it is imperative to unravel the local electronic properties of these materials. We have performed an in-depth study ... -
Conformationally restricted and Bis-aryl guanidinium derivatatives : towards imroved Alpha2-adrenergic affinity and antagonism for the treatment of depression
(Trinity College (Dublin, Ireland). School of Chemistry, 2015)The evident necessity to develop novel therapeutics to treat depression has been recently highlighted by the World Health Organisation who has listed depression to be the second largest global health burden by the year ... -
Consider the editor : textual process in the fiction of Raymond Carver and David Foster Wallace
(Trinity College (Dublin, Ireland). School of English, 2015)This thesis examines the contribution of Gordon Lish and Michael Pietsch to key works of Raymond Carver and David Foster Wallace, respectively. The Prologue situates the two authors in a historical framework, considering ... -
Control of conjugation in the plasmid pSf-R27
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)IncHI plasmids are prevalent amongst the Enterobacteriaceae and can confer a multi-drug resistance phenotype upon the host. IncHI plasmids are also thermosensitive for conjugative transfer. Conjugation can occur optimally ... -
Controlled expression and functional characterisation of SasG - a surface protein of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Staphylococcus aureus colonises the moist squamous epithelium of the anterior nares. One of the adhesins likely to be responsible is the S. aureus surface protein G (SasG) which has sequence similarity with the proteins ...