Browsing by Subject "Neuroscience"
Now showing items 21-40 of 562
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Age-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms.
(2015)BACKGROUND: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset ... -
Ageing, cognitive disorders and professional practice.
(2013)Background: the workforce is ageing. The contribution of older workers is considerable. Their occupational health profiles differ from those of younger workers. Objective: we wished to establish whether consideration ... -
Ageism in Stroke Rehabilitation Studies
(2014)Background: stroke is predominantly a disease of older people. While age bias has been demonstrated in studies of pharmacological therapeutic interventions in stroke, the extent of discrimination by age in stroke rehabilitation ... -
Agreement and disagreement between major emotion recognition systems
(2023)The evaluation of systems that claim to recognize emotions expressed by human beings is a contested and complex task: The early pioneers in this field gave the impression that these systems will eventually recognize a flash ... -
ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS
(2018)Objective: To elucidate the relationship between disease stage in amyotrophic lateral sclerosis (ALS), as measured with the King's Clinical Staging System, and cognitive and behavioral change, measured with the Edinburgh ... -
Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort
(Elsevier, 2011)Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to Alzheimer-type pathology remains poorly defined. We have investigated the BBB in temporal cortex of brain donations from a ... -
Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment.
(2010)In subjects with Mild Cognitive Impairment (MCI) memory disorders indicate a high risk for conversion to Alzheimer?s disease (AD). The objective of this study was to delineate the differences in brain activation between ... -
Alzheimer's disease A� assemblies mediating rapid disruption of synaptic plasticity and memory.
(2012)Alzheimer’s disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic ... -
Amnesia for loss of consciousness is common in vasovagal syncope.
(2011)The aim of this study was to determine the prevalence of amnesia for loss of consciousness (A-LOC) in those who have a history suggestive of vasovagal syncope (VVS) and who develop syncope on head-up tilt (HUT) table ... -
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
(2008)Alzheimer?s disease (AD) constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key ... -
Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
(2014)Background Amyotrophic lateral sclerosis shares characteristics with some cancers, such as onset being more common in later life, progression usually being rapid, the disease affecting a particular cell type, and showing ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
(2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation.
(2013)The anterior thalamic nuclei (ATN), a central component of Papez' circuit, are generally assumed to be key constituents of the neural circuits responsible for certain categories of learning and memory. Supporting evidence ...