Browsing by Author "TAJBER, LIDIA"
Now showing items 21-39 of 39
-
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
CORRIGAN, OWEN; HEALY, ANNE; TAJBER, LIDIA; AMARO, MARIA INES (2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine
TAJBER, LIDIA; SASSE, ASTRID; HEALY, ANNE (2017) -
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
HEALY, ANNE; CORRIGAN, OWEN; TAJBER, LIDIA (2011)The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
HEALY, ANNE; CORRIGAN, OWEN; TAJBER, LIDIA (2011)Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous ... -
Polymer/amorphous salt solid dispersions of ciprofloxacin
TAJBER, LIDIA (2017) -
Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures
O'BRIEN, JOHN EUGENE; HEALY, ANNE MARIE; TAJBER, LIDIA; CORRIGAN, OWEN; MC CABE, THOMAS; PALUCH, KRZYSZTOF (Elsevier, 2011)Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility ... -
Preparation and characterization of amorphous ciprofloxacin-amino acid salts
TAJBER, LIDIA (2017) -
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure
TAJBER, LIDIA; MC CABE, THOMAS; HEALY, ANNE MARIE; O'BRIEN, JOHN EUGENE; CORRIGAN, OWEN; PALUCH, KRZYSZTOF (Elsevier, 2010)Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state ... -
Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids
TAJBER, LIDIA; HEALY, ANNE (2013)The unintentional generation of amorphous character in crystalline active pharmaceutical ingredients (APIs) is an adverse consequence of mechanical activation during dosage form manufacture. In this study, we assess and ... -
Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics.
TAJBER, LIDIA; SASSE, ASTRID (2015) -
Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers
TAJBER, LIDIA; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS; CORRIGAN, OWEN (2014)This work investigates a new type of polyelectrolyte complex nanocarrier composed of hyaluronic acid (HA) and protamine (PROT). Small (approximately 60 nm) and negatively charged nanoparticles (NPs) with a polydispersity ... -
Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt
HEALY, ANNE MARIE; CORRIGAN, OWEN; TAJBER, LIDIA; PALUCH, KRZYSZTOF (Wiley, 2011)The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, ... -
Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation
HEALY, ANNE; TAJBER, LIDIA; CORRIGAN, OWEN (2012) -
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery
TAJBER, LIDIA; EHRHARDT, CARSTEN; PALUCH, KRZYSZTOF; HEALY, ANNE (2013)In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of ... -
Two faces of ciprofloxacin: investigation of proton transfer in solid state transformations
TAJBER, LIDIA; MESALLATI, HANAH NADINE (2016)