Browsing by Author "O'FARRELLY, CLIONA"
Now showing items 21-40 of 66
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The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis.
O'FARRELLY, CLIONA (2006)OBJECTIVE: Cytokines are likely to play a key pathogenic role in thyroid-associated ophthalmopathy (TAO). Anti-cytokine therapy has been proposed to be a possible treatment for active TAO. We aimed to establish the ... -
Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration.
O'FARRELLY, CLIONA (1998) -
Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation.
O'FARRELLY, CLIONA; LAVELLE, EDWARD; CAMPBELL, MATTHEW; MOK, KENNETH (2014)Obesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ... -
Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus
O'FARRELLY, CLIONA; BRADLEY, DANIEL GERARD MARY; LLOYD, ANDREW THOMAS (2009)BACKGROUND: The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important ... -
Evidence of positively selected sites in mammalian alpha-defensins.
O'FARRELLY, CLIONA; FARES, MARIO; LLOYD, ANDREW (2004)Alpha-defensins are a family of mammalian antimicrobial peptides that exhibit variable activity against a panel of microbes, including bacteria, fungi, and enveloped viruses. We have employed a maximum-likelihood approach ... -
Evidence of the adaptive evolution of immune genes in chicken
LLOYD, ANDREW THOMAS; O'FARRELLY, CLIONA; BRADLEY, DANIEL GERARD MARY (2009)The basis for understanding the characteristics of gene functional categories in chicken has been enhanced by the ongoing sequencing of the zebra finch genome, the second bird species to be extensively sequenced. This ... -
EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION
WHELEHAN, CORMAC; O'FARRELLY, CLIONA (Elsevier, 2011)Staphylococcus aureus is a prolific mastitis-causing bacterium that resides naturally in the environment of the dairy cow. The aim of this study was to profile immune gene expression in tissue from the alveolar, ductal, ... -
Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene
BRADLEY, DANIEL GERARD MARY; O'FARRELLY, CLIONA (2013)The enteropathogen Campylobacter jejuni is a major worldwide health and economic burden, being one of the leading causes of bacterial gastroenteritis and commonly linked to postinfectious onset of autoimmune disease. ... -
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
O'FARRELLY, CLIONA; HOKAMP, KARSTEN (2011)Background: Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies have highlighted the role of functional genomics to better ... -
Gliadin antibody detection in gluten enteropathy.
O'FARRELLY, CLIONA (1986)Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be ... -
Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows.
MORRIS, DEREK; O'FARRELLY, CLIONA; NARCIANDI MARTIN, FERNANDO; KENNY, ELAINE (2012) -
Global gene expression analysis of chicken caecal response to Campylobacter jejuni
SHAUGHNESSY, RONAN; O'FARRELLY, CLIONA (Elsevier, 2011)Campylobacter jejuni colonises the caecum of more than 90% of commercial chickens. Even though colonisation is asymptomatic, we hypothesised that it is mediated by activation of several biological pathways. We therefore ... -
Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
O'FARRELLY, CLIONA; DOHERTY, DEREK (2004)Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. ... -
Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
O'FARRELLY, CLIONA; STEVENSON, NIGEL (2014)TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of ... -
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
O'FARRELLY, CLIONA (1999)In this study, we compared the influence of two peptides on the selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, which develop by a unique and partially thymus-independent ... -
Histological changes associated with wheat protein antibodies in the absence of villous atrophy.
O'FARRELLY, CLIONA (1987)A retrospective study was conducted to assess the association of alpha-gliadin antibodies with intraepithelial lymphocyte counts. Twelve subjects with apparently normal small intestinal histology and raised alpha-gliadin ... -
Humoral response to alpha gliadin as serological screening test for coeliac disease.
O'FARRELLY, CLIONA (1987)The diagnostic value of measuring alpha gliadin antibodies in children with suspected coeliac disease has been evaluated prospectively. Jejunal biopsy and alpha gliadin antibody measurements were performed in 77 consecutive ... -
Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.
O'FARRELLY, CLIONA (1986)Features that might distinguish uncomplicated coeliac disease from enteropathy associated T cell lymphoma were investigated. Of 76 patients with coeliac disease, 71 (93%) had raised levels of alpha gliadin antibody and all ... -
IFNL cytokines do not modulate human or murine NK cell functions
O'FARRELLY, CLIONA; GARDINER, CLAIR; WALTON, CLAIR (2014)The interferon-lambda (IFNL) cytokines have been shown to be important in HCV infection with SNPs in the IFNL3 gene associated with both natural and treatment induced viral clearance. We have recently shown that rs1299860 ... -
Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel.
O'FARRELLY, CLIONA (1987)Immunohistological analysis of the cellular composition of the small intestinal mucosa in a group of untreated and treated coeliac patients and non-coeliac control subjects was performed using monoclonal antibodies and an ...