Browsing by Author "KELLEHER, DERMOT P"
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Expression of CD44 on rheumatoid synovial fluid lymphocytes
KELLEHER, DERMOT P (BMJ, 1995)OBJECTIVES--To investigate the involvement of the adhesion molecule CD44 in the homing of lymphocytes to synovial tissue, by examining the density of expression and molecular mass of CD44 on rheumatoid synovial fluid ... -
Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells
KELLEHER, DERMOT P (BMJ, 2001)Conjugated linoleic acid (CLA) is a collective term referring to the positional and geometric isomers of linoleic acid. This novel fatty acid has been shown to have a number of beneficial actions, including immunomodulatory, ... -
Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation
KELLEHER, DERMOT P (BMJ, 1994)Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in ... -
Genetic Polymorphisms and the Risk of Infection Following Esophagectomy
KELLEHER, DERMOT P; MCMANUS, ROSS (Lippincott Williams & Wilkins, 2007)OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. SUMMARY BACKGROUND DATA: Genetic polymorphisms for ... -
Glucocorticoid resistance in inflammatory bowel disease
KELLEHER, DERMOT P (Society for Endocrinology, 2003)Glucocorticoids are potent inhibitors of T cell activation and proinflammatory cytokines and are highly effective treatment for active inflammatory bowel disease (IBD). However, failure to respond, acutely or chronically, ... -
H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
KELLEHER, DERMOT P (British Medical Association, 1998)Extracellular matrix proteins and proteins involved in epithelial adhesion are essential for maintenance of tissue structure. Helicobacter pylori is the major aetiological agent in peptic ulcer disease and has been shown ... -
Helicobacter pylori activates the early growth response 1 protein in gastric epithelial cells
KELLEHER, DERMOT P (American Society for Microbiology, 2004)The early growth response 1 (Egr-1) transcription factor is rapidly induced by various stimuli and is implicated in the regulation of cell growth, differentiation, and gene expression. The aim of this study was to examine ... -
Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators
KELLEHER, DERMOT P (American Society of Microbiology, 1998)Helicobacter pylori colonizes the gastric mucosa, and the infection is related to the development of diverse gastric pathologies, possibly by directly or indirectly affecting epithelial-cell function. We analyzed the ... -
Helicobacter pylori increases proliferation of gastric epithelial cells
KELLEHER, DERMOT P (BMJ, 1996)The direct and indirect effects of helicobacter pylori on cell kinetics of gastric epithelial cell line AGS were investigated by flow cytometric analysis of Ki-67 positive cells and by MTT assay. Flow cytometric analysis ... -
Identification and characterization of a metalloprotease activity from Helicobacter pylori
KELLEHER, DERMOT P (American Society for Microbiology, 1997)Helicobacter pylori produces a metalloprotease with a native molecular size of approximately 200 kDa, as determined by size-exclusion chromatography. Subcellular distribution studies demonstrated that the activity was ... -
Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?
KELLEHER, DERMOT P; O'FARRELLY, CLIONA (BMJ, 1996)BACKGROUND: Activation of circulating T lymphocytes results in expression of HLA-DR, interleukin-2 receptor (IL-2R), transferrin receptor (TrR), and decreased amounts of surface CD3. AIM: To examine the activation status ... -
Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low
KELLEHER, DERMOT P; O'BRIAIN, DONAL SEAN; WEIR, DONALD (BMJ, 2000)BACKGROUND: There is concern that the incidence of non-Hodgkin's lymphoma (NHL) will rise with increasing use of immunosuppressive therapy. AIMS: Our aim was to determine the risk of NHL in a large cohort of patients with ... -
Increased urinary nitrite, a marker of nitric oxide, in active inflammatory bowel disease
KELLEHER, DERMOT P (Taylor and Francis, 2001)BACKGROUND: Nitric oxide (NO) production is increased in inflammatory bowel disease (IBD), and measurement of NO metabolites may be useful for monitoring disease activity. AIMS AND OBJECTIVES: To characterise urinary nitrite ... -
Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study
WINDLE, HENRY; KELLEHER, DERMOT P (2013)Objective: Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been ... -
Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signalling molecules for cytoskeleton-dependent morphological changes in activated T cells
KELLEHER, DERMOT P (Oxford University Press, 1995)Signaling through the leukocyte function-associated antigen 1 (LFA-1) molecule has previously been shown to induce homotypic aggregation in T cells and to induce cytoskeletal changes in T lymphoma cells. In this study we ... -
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
KELLEHER, DERMOT P (American Society for Clinical Investigation, 2009)There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single ... -
Low pH results in co-ordinate regulation of gene expression in oesophageal cells
KELLEHER, DERMOT P; REYNOLDS, JOHN; DUGGAN, SHANE (2006) -
Microalbuminuria correlates with intestinal histopathological grading in patients with inflammatory bowel disease
KELLEHER, DERMOT P (BMJ, 1996)It has previously been shown that microalbuminuria is a useful disease activity marker for inflammatory bowel disease (IBD). Microalbuminuria correlates strongly with the markers of clinical and laboratory disease activity ... -
Microalbuminuria in inflammatory bowel disease
KELLEHER, DERMOT P (BMJ, 1994)Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined ... -
Nanodrug applications in photodynamic therapy.
EHRHARDT, CARSTEN; SENGE, MATHIAS; KELLEHER, DERMOT P; REYNOLDS, JOHN (2011)