Browsing by Author "FALLON, PADRAIC"
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Helminth infection protects mice from anaphylaxis via IL-10 producing B cells
FALLON, PADRAIC (The American Association of Immunologists, 2004)Modulation of the immune system by infection with helminth parasites, including schistosomes, is proposed to reduce the levels of allergic responses in infected individuals. In this study we investigated whether experimental ... -
Helminth Modulation of Lung Inflammation
FALLON, PADRAIC; HAMS, EMILY (2018) -
Helminth therapies: translating the unknown unknowns to known knowns.
FALLON, PADRAIC (2013)The use of live helminth infections is currently in clinical trials as a novel approach for the treatment of a range of allergic and autoimmune diseases. This rapid progression from observational studies some 20 years ago ... -
Helminth-modified pulmonary response protects mice from allergen-induced airway hyper-responsiveness.
FALLON, PADRAIC (The American Association of Immunologists, 2006)It has been shown that the presence of certain helminth infections in humans, including schistosomes, may reduce the propensity to develop allergies in infected populations. Using a mouse model of schistosome worm vs worm ... -
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
FALLON, PADRAIC; HAMS, EMILY; SAUNDERS, SEAN (2011)Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1? and NF-?B via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have ... -
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.
FALLON, PADRAIC (Rockefeller University Press, 2006) -
Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.
FALLON, PADRAIC; NEL, HENDRIK (2011)?-Interferons (IFN-?s) represent one of the first line treatments for relapsing-remitting multiple sclerosis, slowing disease progression while reducing the frequency of relapses. Despite this, more effective, well tolerated ... -
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
SAUNDERS, SEAN; FALLON, PADRAIC; DONNELLY, SEAMAS (2014)Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models ... -
IL-4 induces characteristic Th2 response even in the combined absence of IL-5, IL-9 and IL-13
FALLON, PADRAIC (2002) -
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
FALLON, PADRAIC; NEL, HENDRIK; HAMS, EMILY; SAUNDERS, SEAN (2011)Parasitic-infection studies on rhesus macaque monkeys have shown juvenile animals to be more susceptible to infection than adults, but the immunological mechanism for this is not known. In this study, we investigated the ... -
Impaired development of Th2 cells in IL-13-deficient mice
FALLON, PADRAIC (1998) -
Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism.
FALLON, PADRAIC (The American Association of Immunologists, 2007)The propensity of a range of parasitic helminths to stimulate a Th2 or regulatory cell-biased response has been proposed to reduce the severity of experimental inflammatory bowel disease. We examined whether infection with ... -
Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent.
FALLON, PADRAIC (2013)IL-33 is a recently discovered cytokine involved in induction of Th2 responses and functions as an alarmin. Despite numerous recent studies targeting IL-33, its role in vivo is incompletely understood. Here we investigated ... -
Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
FALLON, PADRAIC (Oxford University Press, 2005)Netherton syndrome is an autosomal recessive multisystemic disorder characterized by congenital ichthyosiform erythroderma, hair shaft defects and atopy, caused by mutations within the human SPINK5 gene. To investigate the ... -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
FALLON, PADRAIC; SHEILS, ORLA; HAMS, EMILY (2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
FALLON, PADRAIC; SAUNDERS, SEAN (2010)Background and Aims: HIF prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. Methods: The effect ... -
Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines
FALLON, PADRAIC (2009-09-17)Interleukin-9 is an immunoregulatory cytokine implicated in the development of asthma and allergy. To investigate the role of IL-9 in vivo, we have generated transgenic mice in which IL-9 is expressed from its own promoter. ... -
Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis.
FALLON, PADRAIC; HAMS, EMILY (2015)