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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/64119

Title: Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
Author: GALLAGHER, PETER THOMAS
FARES, MARIO ALI
Sponsor: 
Name Grant Number
10/RFP/Gen2685

Author's Homepage: http://people.tcd.ie/gallagpt
http://people.tcd.ie/faresm
Keywords: Biochemistry
evolutionary biology
molecular biology
Microorganism
Tat pathway proteins
Issue Date: 2011
Citation: Xiaowei Jiang and Mario A. Fares, Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations, Molecular Biology and Evolution, 28, 11, 2011, 3183 - 3193
Series/Report no.: Molecular Biology and Evolution
28
11
Abstract: Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes’ ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence points to that the secretion of a particular set of proteins mediates microbes’ interaction with the environment. Several systems are involved in this secretion, including the Sec secretion system and the Tat pathway. Shifts in the functions of proteins from the secretion systems may condition the set of secreted proteins and can, therefore, mediate adaptations to new ecological niches. In this manuscript we have investigated processes of functional divergence—a term used here to refer to the emergence of novel functions by the modification of ancestral ones—of Tat pathway proteins using a large set of microbes with different lifestyles. The application of a novel approach to identify functional divergence allowed us to distinguish molecular changes in the three Tat proteins among different groups of archaea and bacteria. We found these changes as well as the composition of secreted proteins to be correlated with differences in microbe’s lifestyles. We identified major signatures of functional divergence in halophilic and thermophilic archaea as well as in pathogenic bacteria. The location of amino acids affected by functional divergence in functionally important domains of Tat proteins made it possible to find the link between the molecular changes in Tat, the set of secreted proteins and the environmental features of the microbes. We present evidence that links specific molecular changes in secretion mediating proteins of microbes to their ecological adaptations.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/64119
Appears in Collections:Genetics (Scholarly Publications)

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