TARA: Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/64079

Title:	Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation
Author:	WILLIAMS, DAVID CLIVE GUNNLAUGSSON, THORFINNUR ELMES, ROBERT
Sponsor:	Irish Research Council for Science Engineering and Technology Higher Education Authority Science Foundation Ireland
Author's Homepage:	http://people.tcd.ie/gunnlaut http://people.tcd.ie/dwillims http://people.tcd.ie/elmesr
Keywords:	quaternarized pdppz derivative 1 dppz derivative cellular death apoptosis
Issue Date:	2011
Publisher:	Royal Society of Chemistry
Citation:	Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, 686 - 688
Series/Report no.:	Chemical Communications;47
Abstract:	The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
Description:	PUBLISHED
URI:	http://hdl.handle.net/2262/64079
Appears in Collections:	Chemistry (Scholarly Publications)

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