The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Pharmacy and Pharmaceutical Sciences >
Pharmacy and Pharmaceutical Sciences >
Pharmacy and Pharmaceutical Sciences (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/64030

Title: Approaches to the safety assessment of engineered nanomaterials (ENM) in food
Author: RADOMSKI, MAREK
Author's Homepage: http://people.tcd.ie/radomskm
Keywords: Nanomaterials
engineered nanomaterials (ENMs)
food
risk assessment
Issue Date: 2011
Publisher: Elsevier
Citation: Cockburn, A., Bradford, R., Buck, N., Constable, A., Edwards, G., Haber, B.,Hepburn, P., Howlett, J., Kampers, F., Klein, C., Radomski, M., Stamm, H., Wijnhoven, S., Wildemann, T., Approaches to the safety assessment of engineered nanomaterials (ENM) in food, Food and Chemical Toxicology, Volume 50, Issue 6, June 2012, Pages 2224-2242
Series/Report no.: Food and Chemical Toxicology;50, 6
2011 Dec 29. [Epub];
Abstract: A systematic, tiered approach to assess the safety of engineered nanomaterials (ENMs) in foods is presented. The ENM is first compared to its non-nano form counterpart to determine if ENM-specific assessment is required. Of highest concern from a toxicological perspective are ENMs which have potential for systemic translocation, are insoluble or only partially soluble over time or are particulate and bio- persistent. Where ENM-specific assessment is triggered, Tier 1 screening considers the potential for translocation across biological barriers, cytotoxicity, generation of reactive oxygen species, inflammatory response, genotoxicity and general toxicity. In silico and in vitro studies, together with a sub-acute repeat-dose rodent study,could be considered for this phase. Tier 2 hazard characterisation is based on a sentinel 90-day rodent study with an extended range of endpoints, additional parameters being investigated case-by-case. Physicochemical characterisation should be performed in a range of food and biological matrices. A default assumption of 100% bioavailability of the ENM provides a ‘worst case’ exposure scenario, which could be refined as additional data become available. The safety testing strategy is considered applicable to variations in ENM size within the nanoscale and to new generations of ENM.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/64030
Appears in Collections:Pharmacy and Pharmaceutical Sciences (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Approaches to the safety assessment of engineered nanomaterials (ENM) in food.pdfAccepted for publication (author's copy) - Peer Reviewed1.2 MBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback