Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review.
Citation:
Stordal, B., Pavlakis, N. and Davey, R., Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review., Cancer Treatment Reviews, 33, 4, 2007, 347 - 357Download Item:
2007-Stordal-CTR-Oxaliplatin.pdf (Published (author's copy) - Peer Reviewed) 262.5Kb
Abstract:
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We
undertook a systematic review of the literature to identify, describe and critique the
clinical and pre-clinical evidence for the use of oxaliplatin in patients with ?cisplatinresistant?
cancer. We identified 25 pre-clinical cell models of platinum resistance and
24 clinical trials reporting oxaliplatin based salvage therapy for cisplatin-resistant
cancer. The pre-clinical data suggests that there is cross-resistance between cisplatin
and oxaliplatin in low-level resistance models. In models with high level resistance
(>10 fold) there is less cross resistance between cisplatin and oxaliplatin, which may
be a reason why oxaliplatin is thought to be active in cisplatin-resistant cancer. In
clinical trials where oxaliplatin has been used as part of salvage therapy for patients
who have failed cisplatin or carboplatin combination chemotherapy, there was a much
lower response rate in patients with platinum-refractory or resistant cancers compared
to platinum-sensitive cancers. This suggests that there may be cross-resistance
between cisplatin and oxaliplatin in the clinic. Oxaliplatin as a single agent had a poor
response rate in cisplatin refractory and resistant cancer. Oxaliplatin performed better
in combination with other agents for the treatment of platinum resistant/refractory
cancer suggesting that the benefit of oxaliplatin may lie in its more favourable toxicity
and ability to be combined with other drugs rather than an underlying activity in
cisplatin resistance. Oxaliplatin therefore should not be considered broadly active in
cisplatin-resistant cancer.
Author's Homepage:
http://people.tcd.ie/stordalbDescription:
PUBLISHED
Author: STORDAL, BRITTA KRISTINA
Other Titles:
Oxaliplatin in Cisplatin-Resistant CancerPublisher:
WB SaundersType of material:
Journal ArticleSeries/Report no:
Cancer Treatment Reviews;33, 4Availability:
Full text availableKeywords:
Cisplatin, OxaliplatinLicences: