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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/62426

Title: The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
Author: FRODL, THOMAS
DONOHOE, GARY (JAMES)
GILL, MICHAEL
CORVIN, AIDEN PETER
NEWELL, FIONA
ROSE, EMMA
FAHEY, CIARA
GARAVAN, HUGH PATRICK
BOKDE, ARUN LAWRENCE WARREN
O'DOHERTY, JOHN PHILIP
MC GRATH, JANE
KELLY, SINEAD
ROBERTSON, IAN H
MORRIS, DEREK
Sponsor: 
Name Grant Number
SFI08/IN.1/B1916-Corvin
HRA/2009/197

Author's Homepage: http://people.tcd.ie/rosee
http://people.tcd.ie/frodlt
http://people.tcd.ie/donoghug
http://people.tcd.ie/mgill
http://people.tcd.ie/acorvin
http://people.tcd.ie/fnewell
http://people.tcd.ie/faheyci
http://people.tcd.ie/garavanh
http://people.tcd.ie/bokdea
http://people.tcd.ie/odoherjp
http://people.tcd.ie/sandersj
http://people.tcd.ie/iroberts
http://people.tcd.ie/morrisdw
Keywords: Neuroscience
schizophrenia
Issue Date: 2012
Publisher: Elsevier
Citation: Emma J. Rose, Ciara Greene, Sinead Kelly, Derek W. Morris, Ian H. Robertson, Ciara Fahey, Sarah Jacobson, John O'Doherty, Fiona N. Newell, Jane McGrath, Arun Bodke, Hugh Garavan, Thomas Frodl, Michael Gill, Aiden P. Corvin, Gary Donohoe, The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals, NeuroImage, 60, 1, 2012, 614 622
Series/Report no.: NeuroImage;
60;
1;
Abstract: A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated how this variation might be mediated at the level of brain structure and function. In healthy individuals (N = 157), voxel based morphometry was used to compare gray matter (GM) volume between homozygous and heterozygous carriers of the ‘G’ allele (i.e. the allele associated with impaired cognition and schizophrenia risk) and homozygous carriers of the non-risk ‘A’ allele. Functional brain imaging data were also acquired from 48 participants during performance of a spatial working memory (SWM) task, and analysed to determine any effect of NOS1 risk status. An a priori region-of-interest analysis identified a significant reduction in ventromedial prefrontal GM volume in ‘G’ allele carriers. Risk carriers also exhibited altered patterns of activation in the prefrontal cortex, caudate, and superior parietal lobe, which were characteristic of abnormal increases in activation in frontoparietal working memory networks and a failure to disengage regions of the default mode network. These functional changes suggest a NOS1-mediated processing inefficiency that may contribute to cognitive dysfunction in schizophrenia. While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/62426
Related links: http://dx.doi.org/10.1016/j.neuroimage.2011.12.054
Appears in Collections:Psychiatry (Scholarly Publications)

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