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Title: The PSD-95/nNOS Complex: New Drugs for Depression?
Sponsor: Health Research Board
Science Foundation Ireland
Author's Homepage:
Keywords: Pharmacology
NMDA receptors
Issue Date: 2012
Citation: Doucet MV, Harkin A, Dev KK, The PSD-95/nNOS Complex: New Drugs for Depression?, Pharmacology & Therapeutics, 133, 2012, 218 - 229
Series/Report no.: Pharmacology & Therapeutics
Abstract: Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically improvement in depressive symptoms only emerges after several weeks of treatment, suggesting that downstream neuronal adaptations rather than the elevation in synaptic monoamine levels are responsible for antidepressant effects. In recent years, the NMDA receptor has emerged as a promising target for treating CNS disorders including stroke, pain and depression. In this review, we outline the molecular mechanisms underlying NMDA receptor signaling in neurons and in particular provide an overview of the role of the NMDAR/PSD-95/nNOS complex in CNS disorders. We discuss novel drug developments made that suggest the NMDAR/PSD-95/nNOS complex as a potential target for the treatment of depression. The review also provides examples of how PDZ-based protein-protein interactions can be exploited as novel drug targets for disease.
Description: PUBLISHED
Appears in Collections:Pharmacy and Pharmaceutical Sciences (Scholarly Publications)

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