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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/61641

Title: A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
Author: BOYLAN, FABIO
Author's Homepage: http://people.tcd.ie/desouzaf
Keywords: Pharmacology
Conium maculatum L
2-pentylpiperidine
Volatile alkaloid
Issue Date: 2012
Publisher: Elsevier
Citation: Niko Radulović, Nevenka Đorđević, Marija Denić, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio Boylan, A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity, Food and Chemical Toxicology, 50, 2, 2012, 274 279
Series/Report no.: Food and Chemical Toxicology;
50;
2;
Abstract: 2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin’s strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20 mg/kg). It was found to be lethal in doses higher than 20 mg/kg.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/61641
Related links: http://dx.doi.org/10.1016/j.fct.2011.10.060
Appears in Collections:Pharmacy and Pharmaceutical Sciences (Scholarly Publications)

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