The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Dental Sciences >
Dental Science >
Dental Science (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/5897

Title: Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
Author: COLEMAN, D.C.
STOKES, C.
MORAN, G.P
SPIERING, M.J.
SULLIVAN, DEREK
Sponsor: Health Research Board
Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/djsullvn
Keywords: Candida dubliniensis
Virulence
Morphogenesis
Infection
Candida albicans
Hyphae
Issue Date: 2007
Publisher: Elsevier
Citation: Stokes, C., Moran, G.P., Spiering, M.J., Cole, G.T., Coleman, D.C., and Sullivan, D.J., Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans, Fungal Genetics and Biology, 44, 2007, 920, 931
Series/Report no.: 44
Fungal Genetics and Biology
Abstract: Candida albicans and Candida dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two infection models. Under all induction conditions tested C. albicans consistently produced hyphae more efficiently than C. dubliniensis. In the oral reconstituted human epithelial model, C. dubliniensis isolates grew exclusively in the yeast form, while the C. albicans strains produced abundant hyphae that invaded and caused significant damage to the epithelial tissue. In the oral intragastric infant mouse infection model, C. dubliniensis strains were more rapidly cleared from the gastrointestinal tract than C. albicans. Immunosupression of Candida infected mice caused dissemination to internal organs by both species, but C. albicans was found to be far more effective at dissemination than C. dubliniensis. These data suggest that a major reason for the comparatively low virulence of C. dubliniensis is its lower capacity to produce hyphae.
Description: PUBLISHED
URI: http://dx.doi.org/10.1016/j.fgb.2006.11.014
http://hdl.handle.net/2262/5897
Other Identifiers: 41338
Appears in Collections:Dental Science (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Stokes2007.pdfMain article368.04 kBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback