Stokes, C., Moran, G.P., Spiering, M.J., Cole, G.T., Coleman, D.C., and Sullivan, D.J., Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans, Fungal Genetics and Biology, 44, 2007, 920, 931
44 Fungal Genetics and Biology
Candida albicans and Candida dubliniensis are very closely related yeast species.
In this study, we have conducted a thorough comparison of the ability of the two species
to produce hyphae and their virulence in two infection models. Under all induction
conditions tested C. albicans consistently produced hyphae more efficiently than C.
dubliniensis. In the oral reconstituted human epithelial model, C. dubliniensis isolates
grew exclusively in the yeast form, while the C. albicans strains produced abundant
hyphae that invaded and caused significant damage to the epithelial tissue. In the oral
intragastric infant mouse infection model, C. dubliniensis strains were more rapidly
cleared from the gastrointestinal tract than C. albicans. Immunosupression of Candida
infected mice caused dissemination to internal organs by both species, but C. albicans
was found to be far more effective at dissemination than C. dubliniensis. These data
suggest that a major reason for the comparatively low virulence of C. dubliniensis is its
lower capacity to produce hyphae.
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