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Title: Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
Author: COLEMAN, D.C.
Sponsor: Health Research Board
Science Foundation Ireland
Author's Homepage:
Keywords: Candida dubliniensis
Candida albicans
Issue Date: 2007
Publisher: Elsevier
Citation: Stokes, C., Moran, G.P., Spiering, M.J., Cole, G.T., Coleman, D.C., and Sullivan, D.J., Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans, Fungal Genetics and Biology, 44, 2007, 920, 931
Series/Report no.: 44
Fungal Genetics and Biology
Abstract: Candida albicans and Candida dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two infection models. Under all induction conditions tested C. albicans consistently produced hyphae more efficiently than C. dubliniensis. In the oral reconstituted human epithelial model, C. dubliniensis isolates grew exclusively in the yeast form, while the C. albicans strains produced abundant hyphae that invaded and caused significant damage to the epithelial tissue. In the oral intragastric infant mouse infection model, C. dubliniensis strains were more rapidly cleared from the gastrointestinal tract than C. albicans. Immunosupression of Candida infected mice caused dissemination to internal organs by both species, but C. albicans was found to be far more effective at dissemination than C. dubliniensis. These data suggest that a major reason for the comparatively low virulence of C. dubliniensis is its lower capacity to produce hyphae.
Description: PUBLISHED
Other Identifiers: 41338
Appears in Collections:Dental Science (Scholarly Publications)

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