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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/58662

Title: Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening
Author: DAVIES, ANTHONY
SERGEEVA, NATALIA
SENGE, MATHIAS
Sponsor: 
Name Grant Number
TRA/2007/11
09/IN.1/B2650

Author's Homepage: http://people.tcd.ie/sengem
http://people.tcd.ie/amitche
http://people.tcd.ie/sergeevn
Keywords: Oncology
Esophageal cancer
Issue Date: 2011
Publisher: Elsevier
Citation: Natalia N. Sergeeva, Marion Donnier-Marechal, Gisela M. Vaz, Anthony M. Davies, Mathias O. Senge, Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening, Bioorganic & Medicinal Chemistry Letters, 21, 15, 2011, 4385-4388
Series/Report no.: Bioorganic & Medicinal Chemistry Letters;
21;
15;
Abstract: A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly taken up by living cells within 5 min. Preliminary in vitro studies have shown that these compounds are selective to esophageal cancer cells and can be used as selective markers in intracellular cancer diagnostics. The materials show a remarkable cytotoxicity towards cancer cells vs. normal as 7 to 1.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/58662
Related links: http://dx.doi.org/10.1016/j.bmcl.2011.06.051
Appears in Collections:Chemistry (Scholarly Publications)

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