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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/57660

Title: Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis
Author: PRENDERGAST, PATRICK JOHN
MURPHY, PAULA
Sponsor: 
Name Grant Number
083539/Z/07/Z

Author's Homepage: http://people.tcd.ie/pmurphy3
http://people.tcd.ie/pprender
Keywords: Bioengineering
Skeletal development
Mechanobiology
Mouse mutant
Muscle contractions
Finite element analysis
Issue Date: 2011
Citation: Nowlan, N.C., Dumas, G., Tajbakhsh, S., Prendergast, P.J., Murphy, P., Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis, Biomechanics and Modeling in Mechanobiology, 11, 1-2, 2011, 207-219
Series/Report no.: Biomechanics and Modeling in Mechanobiology
11
1-2
Abstract: In genetically modified mice with abnormal skeletal muscle development, bones and joints are differentially affected by the lack of skeletal muscle.We hypothesise that unequal levels of biophysical stimuli in the developing humerus and femur can explain the differential effects on these rudiments when muscle is absent. We find that the expression patterns of four mechanosensitive genes important for endochondral ossification are differentially affected in muscleless limbmutants, with more extreme changes in the expression in the humerus than in the femur. Using finite element analysis, we show that the biophysical stimuli induced by muscle forces are similar in the humerus and femur, implying that the removal of muscle contractile forces should, in theory, affect the rudiments equally. However, simulations in which a displacement was applied to the end of the limb, such as could be caused in muscleless mice by movements of the mother or normal littermates, predicted higher biophysical stimuli in the femur than in the humerus. Stimuli induced by limb movement were much higher than those induced by the direct application of muscle forces, and we propose that movements of limbs caused by muscle contractions, rather than the direct application ofmuscle forces, provide themain mechanical stimuli for normal skeletal development. In muscleless mice, passive movement induces unequal biophysical stimuli in the humerus and femur, providing an explanation for the differential effects seen in these mice. The significance of these results is that forces originating external to the embryo may contribute to the initiation and progression of skeletal development when muscle development is abnormal.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/57660
Related links: http://dx.doi.org/10.1007/s10237-011-0304-4
Appears in Collections:Zoology (Scholarly Publications)

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