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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/56873

Title: The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3
Author: O'NEILL, LUKE ANTHONY JOHN
TANNAHILL, GILLIAN
Author's Homepage: http://people.tcd.ie/laoneill
http://people.tcd.ie/tannahig
Keywords: Immunology
Toll-like receptors (TLRs)
Issue Date: 2011
Publisher: Elsevier
Citation: Gillian M. Tannahill, Luke A.J. O'Neill, The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3, FEBS Letter, 585, 11, 2011, 1568-1572
Series/Report no.: FEBS Letter;
585;
11;
Abstract: While it has long been suspected that inflammation participates in the pathogenesis of metabolic disorders such as the insulin resistance that occurs in type 2 diabetes, recent work suggests that this is not the only important interaction between metabolism and inflammation. Inroads into the understanding of the relationship between metabolic pathways and inflammation are indicating that signaling by innate immune receptors such as TLR4 and Nlrp3 regulate metabolism. TLRs have been shown to promote glycolysis, whilst Nlrp3-mediated production of IL-1β causes insulin resistance. A key role for the hypoxia-sensing transcription factor HIF1α in the functioning of macrophages activated by TLRs has also recently emerged. This review will assess recent evidence for these complex interactions and speculate on their importance for innate immunity and inflammation.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/56873
Related links: http://dx.doi.org/10.1016/j.febslet.2011.05.008
Appears in Collections:Biochemistry (Scholarly Publications)

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