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Title: Conjugated Quantum Dots Inhibit the Amyloid β (1 42) Fibrillation Process
Sponsor: Science Foundation Ireland
Author's Homepage:
Keywords: Particles and fields physics
Issue Date: 2011
Citation: Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1 42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, 502386
Series/Report no.: International Journal of Alzheimer's Disease
Abstract: Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstarted that the amyloid beta mixed with and conjugated to dihydrolipoic acid (DHLA)-capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission 2 electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1-42) (Aβ (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
Description: PUBLISHED
Appears in Collections:Chemistry (Scholarly Publications)

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