Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1 42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, 502386
International Journal of Alzheimer's Disease 2011
Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstarted that the amyloid beta mixed with and conjugated to dihydrolipoic acid (DHLA)-capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission
electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1-42) (Aβ (1-42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
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