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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/50746

Title: Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise
Author: MAC ANANEY, OSCAR
REILLY, HEATHER
EGANA, MIKEL
Author's Homepage: http://people.tcd.ie/megana
http://people.tcd.ie/macanao
http://people.tcd.ie/hereilly
Keywords: Physiology
type 2 diabetes
Issue Date: 2011
Citation: MacAnaney O, Reilly H, O'Shea D, Egaña M and Green S, Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise, Diabetes and Vascular Disease Research, 8, 1, 2011, 12 - 21
Series/Report no.: Diabetes and Vascular Disease Research
8
1
Abstract: In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = 10) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 ± 29.2 s) than the heavy (22.2 ± 13.4 s) and lean (21.8 ± 9.3 s) controls, resulting in a significantly greater MRT in the diabetic group (median [IQR] = 30.7 [24.6—46.5] s versus 16.3 [4.3—23.2] s and 18.4 [13.7—19.3] s). These data support the hypothesis and suggest that a slowed hyperaemic response in the exercising limb might contribute to exercise intolerance in diabetic subjects.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/50746
Related links: http://dx.doi.org/10.1177/1479164110389625
Appears in Collections:Physiology (Scholarly Publications)

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