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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/50657

Title: NF-κB regulation: The nuclear response
Author: KELLEHER, DERMOT P
LAWLESS, MATTHEW
MC MANUS, ROSS
GRAY, STEVEN
Sponsor: Higher Education Authority
Wellcome Trust
Author's Homepage: http://people.tcd.ie/rmcmanus
http://people.tcd.ie/kellehdp
http://people.tcd.ie/mlawles
http://people.tcd.ie/grayst
Keywords: Oncology
Immunology
NF-kappa B
Nuclear Regulation
Issue Date: 2009
Publisher: Wiley-Blackwell
Citation: Mankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine, 13, 4, 2009, 631-643
Series/Report no.: Journal of Cellular and Molecular Medicine;
13;
4;
Abstract: Nuclear factor κB (NF-κB) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-κB is involved in a wide range of biological processes including innate and adaptive immunity, inflammation, cellular stress responses, cell adhesion, apoptosis and proliferation. Appropriate regulation of NF-κB is critical for the proper function and survival of the cell. Aberrant NF-κB activity has now been implicated in the pathogenesis of several diseases ranging from inflammatory bowel disease to autoimmune conditions such as rheumatoid arthritis. Systems governing NF-κB activity are complex and there is an increased understanding of the importance of nuclear events in regulating NF-κB's activities as a transcription factor. A number of novel nuclear regulators of NF-κB such asIκB-ζ and PDZ and LIM domain 2 (PDLIM2) have now been identified, adding another layer to the mechanics of NF-κB regulation. Further insight into the functions of these molecules raises the prospect for better understanding and rational design of therapeutics for several important diseases.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/50657
Appears in Collections:Clinical Medicine (Scholarly Publications)

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