F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, 5255-
The aim of this study was to define a quantifiable parameter which would allow for the classification of still-viable penumbra and irreversibly
damaged (ischaemic core) tissue after Middle Cerebral Artery Occlusion (MCAO) in a rat stroke model. Differences in Tissue Sodium Concentration (TSC) levels 
and the rate of TSC increase over time  have previously been reported in animal models of ischemic stroke, with the expressed aim of trying to differentiate between
penumbra and ischaemic core. In the current study, quantitative 23Na Magnetic Resonance Microscopy (qNa-MRM) was used to measure the time course of TSC with
high spatio-temporal resolution, in order to investigate regional variations in TSC behavior in the acute phase in a rodent stroke model.
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