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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/50651

Title: Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T
Author: FAGAN, ANDREW JOHN
WETTERLING, FRIEDRICH
Sponsor: Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/faganan
http://people.tcd.ie/wetterlf
Keywords: Neuroscience
Middle Cerebral Artery Occlusion
Issue Date: 2010
Citation: F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, 5255-
Abstract: The aim of this study was to define a quantifiable parameter which would allow for the classification of still-viable penumbra and irreversibly damaged (ischaemic core) tissue after Middle Cerebral Artery Occlusion (MCAO) in a rat stroke model. Differences in Tissue Sodium Concentration (TSC) levels [1] and the rate of TSC increase over time [2] have previously been reported in animal models of ischemic stroke, with the expressed aim of trying to differentiate between penumbra and ischaemic core. In the current study, quantitative 23Na Magnetic Resonance Microscopy (qNa-MRM) was used to measure the time course of TSC with high spatio-temporal resolution, in order to investigate regional variations in TSC behavior in the acute phase in a rodent stroke model.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/50651
Appears in Collections:Physics (Scholarly Publications)

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