The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Physics >
Physics >
Physics (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/50649

Title: The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase
Author: FAGAN, ANDREW JOHN
WETTERLING, FRIEDRICH
Sponsor: Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/faganan
http://people.tcd.ie/wetterlf
Keywords: Neuroscience
MRM images
Issue Date: 2010
Citation: F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, 5173-
Abstract: Accurate identification of the potentially salvageable ischaemic penumbra is critical in identifying stroke patients who will benefit from thrombolysis and in designing future clinical trials of potential neuroprotectants. The perfusion/diffusion mismatch technique, currently used to detect penumbra is an indirect measure, lacking precision. The ability to accurately quantify TSC in vivo could allow developing of a direct bio-marker for tissue viability in stroke [1]. However, quantitative 23Na-Magnetic Resonance Microscopy (qNa-MRM) of the rat brain is challenging due to the low SNR measured in the MRM images, which results from the 23Na nucleus’s low in vivo concentration, low gyromagnetic ratio, fast transversal signal decay, and the required small voxel size (< 4 μl).
Description: PUBLISHED
URI: http://hdl.handle.net/2262/50649
Appears in Collections:Physics (Scholarly Publications)

Files in This Item:

File Description SizeFormat
5173.pdfPublished (author's copy) - Peer Reviewed267.75 kBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback