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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/48881

Title: Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint
Author: MURPHY, PAULA
PRENDERGAST, PATRICK JOHN
RODDY, KAREN ANN
Sponsor: Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/pprender
http://people.tcd.ie/pmurphy3
http://people.tcd.ie/roddyka
Keywords: Bioengineering
tissue differentiation
Issue Date: 2011
Citation: Karen A. Roddy, Geraldine M. Kelly, Maarten H. van Esc, Paula Murphy, and Patrick J. Prendergast, Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint, Journal of Biomechanics, 44, 11, 2011, 143-149
Series/Report no.: Journal of Biomechanics
44
11
Abstract: Muscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may be a causative factor for the changes in shape of the knee joint as it grows. We do this by predicting the spatial and temporal patterns of biophysical stimuli, where cell proliferation and rudiment shape changes occur within the emerging tissues of the joint over time. We used optical projection tomography (OPT) to create anatomically accurate finite element models of the embryonic knee at three time points (stages) of development. OPT was also used to locate muscle attachment sites and AFM was used to determine material properties. An association was found between the emergence of joint shape, cell proliferation and the pattern of biophysical stimuli generated by embryonic muscle contractions. Elevated rates of growth and cell proliferation in the medial condyle were found to co-localise with elevated patterns of biophysical stimuli including maximum principal stresses and fluid flow, throughout the time period studied, indicating that cartilage growth and chondrocyte proliferation in the epiphysis is potentially related to local patterns of biophysical stimuli. The development of the patella and articular cartilages, which is known to be affected by in ovo immobilisation, could be contributed to by specific patterns of fluid flow, pore pressure and stress in the joint interzone. This suggests that both cartilage growth and in the embryonic joint is regulated by specific patterns of biophysical stimuli and that these stimuli are needed for the correct development of the joint.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/48881
Related links: http://dx.doi.org/10.1016/j.jbiomech.2010.08.039
Appears in Collections:Mechanical & Manufacturing Eng (Scholarly Publications)

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