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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/48880

Title: ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
Author: CORVIN, AIDEN PETER
ROSE, EMMA
DONOHOE, GARY (JAMES)
FRODL, THOMAS
MORRIS, DEREK
GILL, MICHAEL
Author's Homepage: http://people.tcd.ie/mgill
http://people.tcd.ie/acorvin
http://people.tcd.ie/rosee
http://people.tcd.ie/donoghug
http://people.tcd.ie/frodlt
http://people.tcd.ie/morrisdw
Keywords: Psychiatry
schizophrenia
ZNF804A
Issue Date: 2010
Publisher: Elsevier
Citation: Gary Donohoe, Emma Rose, Thomas Frodl, Derek Morris, Ilaria Spoletini, Fulvia Adriano, Sergio Bernardini, CarloCaltagirone, Paola Bossù, Michael Gill, Aiden P. Corvin and Gianfranco Spalletta, ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia, NeuroImage, 54, 3, 2010, 2132-2137
Series/Report no.: NeuroImage;
54;
3;
Abstract: ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared to patient non-carriers, we investigated whether ZNF804A was also associated with variation in brain volume. In a sample of 70 patients and 38 healthy participants we used voxel based morphometry to compare homozygous (AA) carriers of the ZNF804A risk allele to heterozygous and homozygous (AC/CC) non-carriers for both whole brain volume and specific regions implicated in earlier ZNF804A studies –the dorsolateral pre-frontal cortex, the hippocampus, and the amygdala. For patients, but not for controls, we found that homozygous ‘AA’ risk carriers had relatively larger gray matter volumes than heterozygous/homozygous non-carriers (AC/CC), particularly for hippocampal volumes. These data are consistent with our earlier behavioral data and suggest that ZNF804A is delineating a schizophrenia subtype characterized by relatively intact brain volume. Establishing if this represents a discrete molecular pathogenesis with consequences for nosology and treatment will be an important next step in understanding ZNF084A's role in illness risk.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/48880
Related links: http://dx.doi.org/10.1016/j.neuroimage.2010.09.089
Appears in Collections:Psychiatry (Scholarly Publications)

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