Biomaterials Breast Phantom Tissue Mimicking Materials
L.M. Cannon, A.J. Fagan and J.E. Browne, Novel tissue mimicking materials for high frequency breast ultrasound applications, Ultrasound in Medicine and Biology, 37, 1, 2011, 122-135
Ultrasound in Medicine and Biology; 37; 1;
The development and acoustical characterisation of a range of novel agar-based tissue
mimicking material (TMMs) for use in clinically relevant, quality assurance (QA) and
anthropomorphic breast phantoms are presented. The novel agar-based TMMs described in
this study are based on a comprehensive, systematic variation of the ingredients in the
International Electrotechnical Commission (IEC) TMM. A novel, solid fat-mimicking
material was also developed and acoustically characterised. Acoustical characterisation was
carried out using an in-house scanning acoustic macroscope at low (7.5 MHz) and high
frequencies (20 MHz), using the pulse-echo insertion technique. The speeds of sound range
from 1490 to 1570 m. s-1, attenuation coefficients range from 0.1 to 0.9 dB. cm-1. MHz-1 and
relative backscatter ranges from 0 to - 20 dB. It was determined that tissues can be mimicked
in terms of independently controllable speeds of sound and attenuation coefficients. These
properties make these novel TMMs suitable for use in clinically relevant QA and
anthropomorphic phantoms, and would potentially be useful for other high frequency
applications such as intra-vascular and small animal imaging.
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