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Title: The Psychosis Susceptibility gene ZNF804A: associations, functions and phenotypes
Sponsor: Science Foundation Ireland
Health Research Board
Author's Homepage:
Keywords: ZNF804A
Issue Date: 2010
Citation: Donohoe G, Morris DW, Corvin A, The Psychosis Susceptibility gene ZNF804A: associations, functions and phenotypes, Schizophrenia Bulletin, 36, 5, 2010, 904-909
Series/Report no.: Schizophrenia Bulletin
Abstract: As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus. We describe the still scant literature on the biological function of ZNF804A and discuss the efforts being made to characterize and refine the associated phenotype using imaging and neuropsychological approaches. We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology.
Description: PUBLISHED
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Appears in Collections:Psychiatry (Scholarly Publications)

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File Description SizeFormat
ZNF_review_SZ Bull_Final.docAccepted for publication (author's copy) - Peer Reviewed79.5 kBMicrosoft WordView/Open
The Psychosis Susceptibility Gene ZNF804A- Associations, Functions, and Phenotypes.pdfpublished (publisher copy) peer-reviewed76.18 kBAdobe PDFView/Open

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