The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Medicine >
Psychiatry >
Psychiatry (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/40589

Title: Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?
Author: MEANEY, JAMES
KELLEHER, DERMOT P
FAGAN, ANDREW JOHN
FRODL, THOMAS
LISIECKA, DANUTA MIECZYSLAWA
CARBALLEDO, ANGELA
Sponsor: Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/frodlt
http://people.tcd.ie/jmeaney
http://people.tcd.ie/kellehdp
http://people.tcd.ie/faganan
http://people.tcd.ie/lisieckd
http://people.tcd.ie/carbala
Keywords: Psychiatry
major depressive disorder (MDD)
neuroimaging
Issue Date: 2010
Publisher: Nature Publishing Group
Citation: Thomas Frodl, Yolande Ferguson, Andrew Fagan, Danusia Lisiecka, Angela Carballedo, Ian Daly, James Meaney & Dermot Kelleher, Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?, 2010
Abstract: Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide – a high proportion of them related to major depressive disorder (MDD)1. Healthy relatives of patients with major depressive disorder (MDD) are at risk to develop the disease. This higher vulnerability is associated with structural2-4 and functional brain changes5. However, we found using high angular resolution diffusion imaging (HARDI) with 61 diffusion directions that neuron tracts between frontal cortices and limbic as well as temporal and parietal brain regions are characterized by better diffusion coefficients in unaffected relatives (UHR), who managed to stay healthy, compared to healthy volunteers without any family history for a psychiatric disease (HC). Moreover, those UHR with stronger fibre connections better managed incidences of adversity in early life without later developing depression, while in HC axonal connections were found to be decreased when they had early-life adversity. Altogether these findings indicate the presence of stronger neural fibre connections in UHR, which seem to be associated with resilience against environmental stressors, which we suggest occur through epigenetic mechanisms.
Description: IN_PRESS
URI: http://hdl.handle.net/2262/40589
Related links: http://hdl.handle.net/10101/npre.2010.4793.1
Appears in Collections:Psychiatry (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Microstructural Correlates of Resilience against Major Depressive Disorder - Epigenetic Mechanisms.pdfPre-print (author's copy) - Non-Peer Reviewed1.7 MBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback