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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/40199

Title: AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
Author: SULLIVAN, DEREK
MORAN, GARY
COLEMAN, DAVID
Sponsor: Health Research Board
Author's Homepage: http://people.tcd.ie/djsullvn
http://people.tcd.ie/gmoran
http://people.tcd.ie/dcoleman
Keywords: Dental Science
Microbiology
Candida dubliniensis
Issue Date: 2005
Citation: PINJON E, MORAN GP, COLEMAN DC, SULLIVAN DJ, AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS, BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 5, 2005, 1210 - 1214
Series/Report no.: BIOCHEMICAL SOCIETY TRANSACTIONS
33
5
Abstract: Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. Isolates of C. dubliniensis are generally susceptible to commonly used azole antifungal agents; however, resistance has been observed in clinical isolates and can be induced by in vitro exposure. Molecular mechanisms of azole resistance in C. dubliniensis include increased drug efflux, modifications of the target enzyme and alterations in the ergosterol biosynthetic pathway.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/40199
Related links: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16246083&dopt=Abstract
Appears in Collections:Dental Science (Scholarly Publications)

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