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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/39644

Title: Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
Author: MITCHELL, KEVIN
LITTLE, GRAHAM
Sponsor: Irish Research Council for Science Engineering and Technology
Health Research Board
Medical Research Council
Science Foundation Ireland
Author's Homepage: http://people.tcd.ie/kemitche
http://people.tcd.ie/littleg
Keywords: Genetics
Issue Date: 2009
Citation: Little, GE, López-Bendito, G, Rünker, AE, García, N, Piñon, MC, Chédotal, A, Molnár, Z, Mitchell, KJ, Specificity and plasticity of thalamocortical connections in Sema6A mutant mice., PLoS biology, 7, 4, 2009, 98
Series/Report no.: PLoS biology;
7;
4;
Abstract: The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate innervation. We show here that Sema6A mutants provide a unique model to test current ideas on the interactions between subcortical and cortical guidance mechanisms and cortical regionalization. In these mutants, axons from the dorsal lateral geniculate nucleus (dLGN) are misrouted in the ventral telencephalon. This leads to invasion of presumptive visual cortex by somatosensory thalamic axons at embryonic stages. Remarkably, the misrouted dLGN axons are able to find their way to the visual cortex via alternate routes at postnatal stages and reestablish a normal pattern of thalamocortical connectivity. These findings emphasize the importance and specificity of cortical cues in establishing thalamocortical connectivity and the spectacular capacity of the early postnatal cortex for remapping initial sensory representations.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/39644
Appears in Collections:Genetics (Scholarly Publications)

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