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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/36528

Title: Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
Author: NOLAN, DEREK
Author's Homepage: http://people.tcd.ie/denolan
Keywords: Biochemistry
Issue Date: 2005
Publisher: American Association for the Advancement of Science
Citation: Perez-Morga D., Vanhollebeke B., Paturiaux-Hanocq F., Nolan D.P., Lins L., Homble F., Vanhamme L., Tebabi P., Pays A., Poelvoorde P., Jacquet A., Brasseur R., Pays E., Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes, Science, 309, 2005, 469, 472
Series/Report no.: Science
309
Abstract: Apolipoprotein L-I is the trypanolytic factor of human serum. Here we show that this protein contains a membrane pore-forming domain functionally similar to that of bacterial colicins, flanked by a membrane-addressing domain. In lipid bilayer membranes, apolipoprotein L-I formed anion channels. In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed.
Description: PUBLISHED
URI: http://dx.doi.org/10.1126/science.1114566
http://hdl.handle.net/2262/36528
Appears in Collections:Biochemistry (Scholarly Publications)

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