Farmer A, Breen G, Brewster S, Craddock N, Gill M. Korsun A, Maier W, Middleton L, Mors O, Owen M, Perry J, Preisig M, Reitchel M, Reich T, McGuffin P. (2004), The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study, BioMed Central Psychiatry, 4, 2004, 42
BioMed Central Psychiatry 4
Background: The Depression Network Study (DeNt) is a multicentre study designed to identify
genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian
families. This study presents the method and socio-demographic details of the first 470 affected
sibling pairs recruited from 8 different sites in Europe and the United States of America.
Methods: Probands fulfilling either the Diagnostic and Statistical Manual 4th edition (DSM-IV) or
the International Classification of Diseases 10th edition (ICD-10) criteria for recurrent unipolar
depression of moderate or severe degree and who had at least one similarly affected sibling were
eligible for the study. Detailed clinical and psychological assessments were undertaken on all
subjects including an interview using the Schedules for Clinical Assessment in Neuropsychiatry.
Blood samples were collected from all participants to extract DNA for linkage analysis.
Results: The different sites used different recruitment strategies depending on local health care
organisation but despite this there was remarkable similarity across sites for the subjects recruited.
Although the Bonn site had significantly older subjects both for age of onset and age at interview,
for the sample as a whole, subjects were interviewed in their mid-40s and had experienced the
onset of their recurrent depression in their 20s. Preliminary genome screening was able to include
929 out of the 944 subjects (98.4%) typed at 932 autosomal and 544 X chromosome markers
Conclusions: This paper describes the methodology and the characteristics of the subjects from
the 414 families included in the first wave of genotyping from the multi-site DeNT study. Ultimately
the study aims to collect affected sibling pairs from approximately 1200 families.
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