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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/34808

Title: Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Author: CORVIN, AIDEN
GILL, MICHAEL
MORRIS, DEREK WILLIAMS
Sponsor: Science Foundation Ireland
Health Research Board
Author's Homepage: http://people.tcd.ie/morrisdw
Keywords: Psychiatry
Issue Date: 2008
Publisher: Nature Publishing Group
Citation: Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, Macintyre DJ, Maclean AW, St Clair D, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Nicol Ferrier I, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH; Wellcome Trust Case Control Consortium, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N ‘Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder’ in Nature Genetics, 40, (9), 2008, pp 1056 - 1058
Series/Report no.: Nature Genetics
40
9
Abstract: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Description: PUBLISHED
URI: http://www.nature.com/doifinder/10.1038/ng.209
http://hdl.handle.net/2262/34808
Appears in Collections:Psychiatry (Scholarly Publications)

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