The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Medicine >
Clinical Medicine >
Clinical Medicine (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/34487

Title: Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study.
Author: COAKLEY, DAVIS
COEN, ROBERT
SCOTT, JOHN MARTIN
MOLLOY, ANNE MARIE
LAWLOR, BRIAN
CUNNINGHAM, COLM
Author's Homepage: http://people.tcd.ie/amolloy
http://people.tcd.ie/dcoakley
http://people.tcd.ie/rcoen
http://people.tcd.ie/jscott
http://people.tcd.ie/lawlorba
http://people.tcd.ie/cunninco
Keywords: Clinical Medicine
Issue Date: 2008
Citation: A.V. Chin, D.J. Robinson, H. O'Connell, F. Hamilton, I. Bruce, R. Coen, B. Walsh, D. Coakley, A. Molloy, J. Scott, B.A. Lawlor, C.J. Cunningham., Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study., Age and Ageing, 37, 5, 2008, 559, 564
Series/Report no.: Age and Ageing
37
5
Abstract: BACKGROUND: population studies suggest that cardiovascular risk factors may be associated with cognitive impairment. Epidemiological studies evaluating individual markers of vascular disease as risk factors for cognitive dysfunction have yielded inconsistent results. Homocysteine has emerged as a marker consistently associated with poorer outcomes. Existing studies have largely examined individual vascular risks in isolation and have tended to ignore patient psychological status. OBJECTIVE: to investigate the association between markers of vascular disease and cognition in a community-dwelling non-demented elderly population while adjusting for vascular and non-vascular confounds. DESIGN: cross-sectional community based assessment. Participants: 466 subjects with mean age 75.45 (s.d., 6.06) years. 208 (44.6%) were male. RESULTS: higher levels of homocysteine were consistently associated with poorer performance in tests assessing visual memory and verbal recall. No other vascular biomarker was found to be associated with cognitive performance. Factors such as alcohol use, tea intake, life satisfaction, hypertension and smoking were positively correlated with global cognitive performance. Negative correlations existed between cognitive performance and depression, past history of stroke, intake of fruit and use of psychotropic medication. CONCLUSIONS: homocysteine was the only vascular biomarker associated with poorer function in a number of domains on neuropsychological testing, independent of vascular and non-vascular confounds. Other psychosocial factors may need to be taken into account as potential confounds in future studies investigating cognition.
Description: PUBLISHED
URI: http://dx.doi.org/10.1093/ageing/afn144
http://hdl.handle.net/2262/34487
Appears in Collections:Clinical Medicine (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Vascular biomarkers of cognitive performance in a community-based elderly population - the Dublin Healthy Ageing study.pdfpublished (publisher copy) peer-reviewed118.85 kBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback