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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/34393

Title: Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease
Author: KELLEHER, DERMOT P
Author's Homepage: http://people.tcd.ie/kellehdp
Keywords: Clinical Medicine
Issue Date: 1989
Publisher: BMJ
Citation: Kelleher, D. 'Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease' in Gut, 30, (6), 1989, pp 839 - 844
Series/Report no.: Gut
30
6
Abstract: T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced defect in suppressor cell function was observed in the patient group but not in matched controls irrespective of whether B cells or monocytes were used as the stimulus. This defect was observed for IgG, A and M. This defect was seen both in patients with active disease and with inactive CD suggesting the possibility that a primary regulatory defect might exist in this disease. The patient group displayed normal helper cell function.
Description: PUBLISHED
URI: http://dx.doi.org/10.1136/gut.30.6.839
http://hdl.handle.net/2262/34393
Appears in Collections:Administrative Staff Authors (Scholarly Publications)

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