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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/33701

Title: A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
Author: BOWIE, ANDREW
O'NEILL, LUKE ANTHONY JOHN
Author's Homepage: http://people.tcd.ie/laoneill
Keywords: Biochemistry
Issue Date: 2000
Publisher: National Academy of Sciences
Citation: A. Bowie, E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower and L. A. O'Neill ‘A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling’ in Proceedings of the National Academy of Sciences of the United States of America, 97, (18), 2000, pp 10162-10167
Series/Report no.: Proceedings of the National Academy of Sciences of the United States of America
97
18
Abstract: Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 receptor (TIR) domain, a motif that defines the IL-1/Toll-like receptor (TLR) superfamily of receptors, which have a key role in innate immunity and inflammation. When expressed in mammalian cells, the protein products of both ORFs were shown to interfere specifically with IL-1 signal transduction. A46R partially inhibited IL-1-mediated activation of the transcription factor NFkappaB, and A52R potently blocked both IL-1- and TLR4-mediated NFkappaB activation. MyD88 is a TIR domain-containing adapter molecule known to have a central role in both IL-1 and TLR4 signaling. A52R mimicked the dominant-negative effect of a truncated version of MyD88 on IL-1, TLR4, and IL-18 signaling but had no effect on MyD88-independent signaling pathways. Therefore, A46R and A52R are likely to represent a mechanism used by vaccinia virus of suppressing TIR domain-dependent intracellular signaling.
Description: PUBLISHED
URI: www.pnas.org/cgi/doi/10.1073/pnas.160027697
http://hdl.handle.net/2262/33701
Appears in Collections:Biochemistry (Scholarly Publications)

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