The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Biochemistry & Immunology >
Biochemistry >
Biochemistry (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/33448

Title: Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Author: O'NEILL, LUKE ANTHONY JOHN
PALSSON, EVA
Author's Homepage: http://people.tcd.ie/laoneill
Keywords: CD14, LPS, Mal, MyD88, TLR4
Issue Date: 2004
Publisher: British Society for Immunology
Citation: E. M. Palsson-McDermott and L. A. O'Neill ‘Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4’ in Immunology, 113, (2), 2004, pp 153-62
Series/Report no.: Immunology
113
2
Abstract: An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll-like receptor 4 (TLR4) – but also in a better appreciation of the complexity of the signalling pathways activated by LPS. Soon after the discovery of TLR4, the formation of a receptor complex in response to LPS, consisting of dimerized TLR4 and MD-2, was described. Intracellular events following the formation of this receptor complex depend on different sets of adapters. An early response, which is dependent on MyD88 and MyD88-like adapter (Mal), leads to the activation of nuclear factor-κB (NF-κB). A later response to LPS makes use of TIR-domain-containing adapter-inducing interferon-β (TRIF) and TRIF-related adapter molecule (TRAM), and leads to the late activation of NF-κB and IRF3, and to the induction of cytokines, chemokines, and other transcription factors. As LPS signal transduction is an area of intense research and rapid progress, this review is intended to sum up our present understanding of the events following LPS binding to TLR4, and we also attempt to create a model of the signalling pathways activated by LPS.
Description: PUBLISHED
URI: http://dx.doi.org/10.1111/j.1365-2567.2004.01976.x.
http://hdl.handle.net/2262/33448
Appears in Collections:Biochemistry (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.pdfpublished (publisher copy) peer-reviewed401.18 kBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback