TARA: Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia

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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/30027

Title:	Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia
Author:	GARAVAN, HUGH PATRICK
Sponsor:	Irish Research Council for Humanities and Social Sciences Health Research Board
Author's Homepage:	http://people.tcd.ie/garavanh
Keywords:	Psychiatry schizophrenia
Issue Date:	2008
Publisher:	Elsevier
Citation:	Magno, E., Yeap, S., Thakore, J.H., Garavan, H., De Sanctis, P., Javitt, D.C., & Foxe, J.J. ‘Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia’ in Biological Psychiatry, 64, 1, (2008), pp 385 - 391
Series/Report no.:	Biological Psychiatry 64 1
Abstract:	Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies has been impaired MMN generation in schizophrenia, which has been interpreted as evidence for fundamental deficits in automatic auditory sensory processing. The aim of this study was to investigate the extent to which dysfunction in MMN generation might represent an endophenotypic marker for schizophrenia.
Description:	PUBLISHED
URI:	http://dx.doi.org/10.1016/j.biopsych.2008.03.019 http://hdl.handle.net/2262/30027
ISSN:	0006-3223
Appears in Collections:	Psychology (Scholarly Publications)

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