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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/29066

Title: Hydrogen peroxide as a clinical irrigation solution: A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface
Author: KELLY, DANIEL
Author's Homepage: http://people.tcd.ie/kellyd9
Keywords: Hydrogen Peroxide
Bone-Cement Interface
Arthroplasty
Issue Date: 2007
Publisher: IOS Press
Citation: Guerin, S., O’Reilly, P., O’Byrne, J. and Kelly, D.J, ‘Hydrogen peroxide as a clinical irrigation solution: A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface’ in Biomedical Materials and Engineering, 17,(6), 2007, pp 379 - 386
Series/Report no.: Biomedical Materials and Engineering
17
6
Abstract: Hydrogen peroxide has been used for decades as an effervescent haemostatic agent in arthroplasty. Recently it has been shown to adversely affect the material properties of PMMA. We aim to assess whether any such deleterious effects are demonstrated in an experimental model which mimics the clinical use of hydrogen peroxide. Matched pairs of cancellous bone samples were treated with a swab soaked in either saline or a 3% solution of hydrogen peroxide, prior to manufacture of cement-bone constructs using Palacos or Simplex cement. Thirty pairs were then compared by subjecting them to a torsional shear force until failure and a further thirty pairs were tested to failure in tension. There was no significant difference between the mean torques to failure for the Palacos-peroxide group versus the Palacos-saline group, or the Simplexperoxide versus the Simplex-saline group (p=0.31 and 0.71 respectively). Similarly there was no significant difference between the mean tension loads to failure for the Palacos-peroxide group versus the Palacos-saline group, and the Simplex-peroxide versus the Simplex-saline group (p=0.79 and 0.23 respectively). We conclude that the use of hydrogen peroxide as an effervescent haemostatic agent has no detrimental effect on the mechanical integrity of the bonecement interface when compared to normal saline.
Description: PUBLISHED
URI: http://iospress.metapress.com/content/w115795826p06161/fulltext.pdf
http://hdl.handle.net/2262/29066
ISSN: 0959-2989
Appears in Collections:Mechanical & Manufacturing Eng (Scholarly Publications)

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