The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Engineering >
Mechanical & Manufacturing Eng >
Mechanical & Manufacturing Eng (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/29047

Title: Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis
Author: KELLY, DANIEL
PRENDERGAST, PATRICK JOHN
Author's Homepage: http://people.tcd.ie/kellyd9
Keywords: tissue engineering
cartilage
confined compression
biomechanics
Issue Date: 2004
Publisher: Springer
Citation: D.J. Kelly and P.J. Prendergast ‘Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis’ in Medical & Biological Engineering & Computing, 45, (1), 2004, pp 9 - 13
Series/Report no.: Medical & Biological Engineering & Computing
45
1
Abstract: The structure and functionality of tissue-engineered cartilage is determined by the tissue culture conditions and mechanical conditioning during growth. The quality of tissue-engineered cartilage can be evaluated using tests such as the confined compression test. Tissue-engineered cartilage constructs usually consist of an outer layer of cartilage and an inner core of either undeveloped cartilage or degrading scaffold material. A biphasic poro-elastic finite element model was used to demonstrate how such a core influences the reaction force-time curve obtained from a confined compression test. The finite element model predicted that higher volumes of degraded scaffold in the inner core would reduce the aggregate modulus calculated from the confined compression test and raised the estimate of tissue permeability. The predicted aggregate modulus reduced from 0.135 MPa, for a homogenous construct, to 0.068 MPa, for a construct that was only 70% cartilaginous. It was found that biphasic poro-elastic finite modelling should be used in preference to a one-dimensional model that assumed homogeneity in estimating the properties of tissue-engineered cartilage.
Description: PUBLISHED
URI: http://dx.doi.org/10.1007/BF02351005
http://hdl.handle.net/2262/29047
ISSN: 0140-0118
Appears in Collections:Mechanical & Manufacturing Eng (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Kelly - 2004 - MBEC.pdfpublished (author copy) peer-reviewed194.76 kBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback