The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Engineering >
Mechanical & Manufacturing Eng >
Mechanical & Manufacturing Eng (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/29029

Title: The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents
Author: KELLY, DANIEL
Sponsor: Enterprise Ireland
Author's Homepage: http://people.tcd.ie/kellyd9
Keywords: Mechanical & Manufacturing Engineering
Issue Date: 2009
Publisher: Elsevier
Citation: Pericevic, I., Lally, C., Toner, D. and Kelly, D.J., ‘The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents’ in Medical Engineering and Physics, 31, (4), 2009, pp 428-433
Series/Report no.: Medical Engineering and Physics
31
4
Abstract: Intracoronary stent implantation is a mechanical procedure, the success of which depends to a large degree on the mechanical properties of each vessel component involved and the pressure applied to the balloon. Little is know about the influence of plaque composition on arterial overstretching and the subsequent injury to the vessel wall following stenting. An idealised finite element model was developed to investigate the influence of both plaque type (hypercellular, hypocellular and calcified) and stent inflation pressures (9, 12 and 15 atm) on vessel and plaque stresses during the implantation of a balloon expandable coronary stent into an idealised stenosed artery. The plaque type was found to have a significant influence on the stresses induced within the artery during stenting. Higher stresses were predicted in the artery wall for cellular plaques, while the stiffer calcified plaque appeared to play a protective role by reducing the levels of stress within the arterial tissue for a given inflation pressure. Higher pressures can be applied to calcified plaques with a lower risk of arterial vascular injury which may reduce the stimulus for in-stent restenosis. Results also suggest that the risk of plaque rupture, and any subsequent thrombosis due to platelet deposition at the fissure, is greater for calcified plaques with low fracture stresses.
Description: PUBLISHED
URI: http://dx.doi.org/10.1016/j.medengphy.2008.11.005
http://hdl.handle.net/2262/29029
ISSN: 1350-4533
Appears in Collections:Mechanical & Manufacturing Eng (Scholarly Publications)

Files in This Item:

File Description SizeFormat
Pericevic - 2009 - MEP.pdfpublished (author copy) peer-reviewed1.04 MBAdobe PDFView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback