Donohoe, G., O’Reilly, R., Clarke, S., Meredith S., Greene B., Morris, D., Nangle, J.-M., Schwaiger, S., Gill, M., Corvin, A. Garavan, H., Robertson, I. , ‘Do antisaccade deficits in schizophrenia provide evidence of a specific inhibitory function?’ in Journal of the International Neuropsychological Society, 12, 2006, pp 901 - 906
Journal of the International Neuropsychological Society 12
Background: Despite its inhibitory control requirements, antisaccade deficits have been consistently associated with
working memory impairments in schizophrenia. We investigated whether variance in antisaccade per formance could
be better accounted for in terms of a specific inhibitory function. Method: We assessed 48 clinically stable
out-patients with schizophrenia on an antisaccade task, as well as on measures of spatial and verbal working
memory, sustained selective attention, and a simple motoric go 0 no-go measure of response inhibition. Results: In a
stepwise multiple regression analysis, go 0 no-go task per formance accounted for a considerably greater percentage
of variance in antisaccade per formance (25.3%) than either working memory (8.4%) or sustained selective attention
task (9.1%). Discussion: We conclude that antisaccade deficits in schizophrenia appear to be better understood in
terms of a specific deficit of inhibitory control than in terms of more general difficulties with context maintenance
or goal neglect.
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